All Outputs (2)

POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer (2014)
Journal Article
Sharpe, D. J., Orr, K. S., Moran, M., White, S. J., McQuaid, S., Lappin, T. R., …James, J. A. (2014). POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer. Oncotarget, 5(18), https://doi.org/10.18632/oncotarget.2492

HOX genes are master regulators of organ morphogenesis and cell differentiation during embryonic development, and continue to be expressed throughout post-natal life. To test the hypothesis that HOX genes are dysregulated in head and neck squamous ce... Read More about POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer.

Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia (2014)
Journal Article
Kettyle, L. M., Liberante, F. G., & Thompson, A. (2014). Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia. Methods in Molecular Biology, 1196, https://doi.org/10.1007/978-1-4939-1242-1_21

Drug discovery and development are often hampered by lack of target identification and clinical tractability. Repurposing of approved drugs to life-threatening diseases such as leukemia is emerging as a promising alternative approach. Connectivity ma... Read More about Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia.