CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes

Kondrashov, Alexander; Mohd Yusof, Nurul A.N.; Hasan, Alveera; Goulding, Jo�lle; Kodagoda, Thusharika; Hoang, Duc M.; Vo, Nguyen T.N.; Melarangi, Tony; Dolatshad, Nazanin; Gorelik, Julia; Hill, Stephen J.; Harding, Sian E.; Denning, Chris

doi:10.1016/j.omtm.2020.10.019

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CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes (2020)
Journal Article
Kondrashov, A., Mohd Yusof, N. A., Hasan, A., Goulding, J., Kodagoda, T., Hoang, D. M., Vo, N. T., Melarangi, T., Dolatshad, N., Gorelik, J., Hill, S. J., Harding, S. E., & Denning, C. (2021). CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes. Molecular Therapy - Methods and Clinical Development, 20, 39-53. https://doi.org/10.1016/j.omtm.2020.10.019

© 2020 During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (β2AR) is influenced by polymorphic variants. The functional impact of such polymorphisms has been suggested from data derived from genetic association... Read More about CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes.