All Outputs (2)

In Vivo Evaluation of Pam2Cys‐Modified Cancer‐Testis Antigens as Potential Self‐Adjuvanting Cancer Vaccines (2025)
Journal Article
Aljohani, S., Edmonds, A., Castelletto, V., Seitsonen, J., Hamley, I., Symonds, P., Brentville, V. A., Durrant, L. G., & Mitchell, N. (2025). In Vivo Evaluation of Pam2Cys‐Modified Cancer‐Testis Antigens as Potential Self‐Adjuvanting Cancer Vaccines. Journal of Peptide Science, 31(6), Article e70022. https://doi.org/10.1002/psc.70022

Peptide-based vaccines, formulated with an appropriate adjuvant, offer a versatile platform for targeted cancer immunotherapy. While adjuvants are usually coadministered for nucleic acid and protein vaccines, synthetic peptide antigens afford a more... Read More about In Vivo Evaluation of Pam2Cys‐Modified Cancer‐Testis Antigens as Potential Self‐Adjuvanting Cancer Vaccines.

A Modular and Scalable Route to Protected Cyclopropane Amino Acid Building Blocks (2025)
Journal Article
Swan, C. T., Edmonds, A. G., Argent, S. P., & Mitchell, N. J. (2025). A Modular and Scalable Route to Protected Cyclopropane Amino Acid Building Blocks. Organic Letters, 27(18), 4800-4805. https://doi.org/10.1021/acs.orglett.5c01341

An improved method for the synthesis of noncanonical cyclopropane amino acids from common laboratory reagents is described, avoiding the use of neurotoxic oxidants or precious metal catalysts. Intramolecular isocyanate trapping via a Hofmann rearrang... Read More about A Modular and Scalable Route to Protected Cyclopropane Amino Acid Building Blocks.