Effect of Combining EGFR Tyrosine Kinase Inhibitors and Cytotoxic Agents on Cholangiocarcinoma Cells

Boonsri, Boonyakorn; Yacqub-Usman, Kiren; Thintharua, Pakpoom; Myint, Kyaw Zwar; Sae-Lao, Thannicha; Collier, Pam; Suriyonplengsaeng, Chinnawut; Larbcharoensub, Noppadol; Balasubramanian, Brinda; Venkatraman, Simran; Egbuniwe, Isioma U.; Gomez, Dhanwant; Mukherjee, Abhik; Kumkate, Supeecha; Janvilisri, Tavan; Zaitoun, Abed M; Kuakpaetoon, Thiti; Tohtong, Rutaiwan; Grabowska, Anna M.; Bates, David O.; Wongprasert, Kanokpan

doi:10.4143/crt.2020.585

All Outputs (3)

High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer (2020)
Presentation / Conference Contribution
Heyman, T., Joseph, C., Craze, M., Green, A., Nolan, C., Rueda, O., …Mukherjee, A. (2020). High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer.

Background & objectives
TIMP2, tissue inhibitor of matrix-metalloproteinase 2, inhibits the matrix-metalloproteinase, MMP2, but may activate pro-MMP2. Hence its correlation with prognosis in breast cancer (BC) is contradictory. This study investigat... Read More about High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer.

High micro-vessel density correlates with higher peri-tumoural immune response in colorectal cancer (2020)
Presentation / Conference Contribution
Raghuram, G., Fadhil, W., Sculthorpe, D., Ilyas, M., & Mukherjee, A. (2020). High micro-vessel density correlates with higher peri-tumoural immune response in colorectal cancer.

Background & objectives
Microvessels, a significant component of the tumour microenvironment in colorectal cancer (CRC), have traditionally been assessed in full-face sections. This study aimed to assess the microvessel density (MVD) in CRC tissue m... Read More about High micro-vessel density correlates with higher peri-tumoural immune response in colorectal cancer.

Effect of Combining EGFR Tyrosine Kinase Inhibitors and Cytotoxic Agents on Cholangiocarcinoma Cells (2020)
Journal Article
Boonsri, B., Yacqub-Usman, K., Thintharua, P., Myint, K. Z., Sae-Lao, T., Collier, P., …Wongprasert, K. (2020). Effect of Combining EGFR Tyrosine Kinase Inhibitors and Cytotoxic Agents on Cholangiocarcinoma Cells. Cancer Research and Treatment, 53(2), 457-470. https://doi.org/10.4143/crt.2020.585

Purpose The potential of members of the epidermal growth factor receptor (ErbB) family as drug targets in cholangiocarcinoma (CCA) has not been extensively addressed. Although phase III clinical trials showed no survival benefits of erlotinib in pati... Read More about Effect of Combining EGFR Tyrosine Kinase Inhibitors and Cytotoxic Agents on Cholangiocarcinoma Cells.