High micro-vessel density correlates with higher peri-tumoural immune response in colorectal cancer

Raghuram, Gayatri; Fadhil, Wakkas; Sculthorpe, Declan; Ilyas, Mohammad; Mukherjee, Abhik

Abstract

Background & objectives
Microvessels, a significant component of the tumour microenvironment in colorectal cancer (CRC), have traditionally been assessed in full-face sections. This study aimed to assess the microvessel density (MVD) in CRC tissue microarrays (TMAs) and determined correlations with clinicopathological variables.
Methods
TMAs from 1000 consecutive cases (2008-2014) of CRC from a tertiary centre were immunostained with clinical grade CD34 antibody (1:500 dilution). Stained microvessels and core areas were annotated on digital images (Nanozoomer) and assessed (3D Histech). The MVD was adjudged in luminal, central and peripheral tumour cores as well as adjacent normal, and results correlated to clinicopathological variables (SPSS).
Results
Of 985 assessable cases, 490 had a high overall tumour MVD. The mean tumour MVD was lower than the mean MVD in the adjacent normal area (p

Citation

Raghuram, G., Fadhil, W., Sculthorpe, D., Ilyas, M., & Mukherjee, A. (2020). High micro-vessel density correlates with higher peri-tumoural immune response in colorectal cancer

• Conference Name: 32nd Congress of the ESP and XXXIII International Congress of the IAP
• Conference Location: Glasgow
• Start Date: Dec 6, 2020
• End Date: Dec 8, 2020
• Acceptance Date: May 27, 2020
• Online Publication Date: Dec 8, 2020
• Publication Date: Dec 8, 2020
• Deposit Date: Aug 27, 2020
• Publicly Available Date: Dec 8, 2020
• Public URL: https://nottingham-repository.worktribe.com/output/4854838
• Related Public URLs: https://www.esp-congress.org/