Skip to main content

Research Repository

Advanced Search

High micro-vessel density correlates with higher peri-tumoural immune response in colorectal cancer

Raghuram, Gayatri; Fadhil, Wakkas; Sculthorpe, Declan; Ilyas, Mohammad; Mukherjee, Abhik

High micro-vessel density correlates with higher peri-tumoural immune response in colorectal cancer Thumbnail


Authors

Gayatri Raghuram

Wakkas Fadhil

Mohammad Ilyas



Abstract

Background & objectives
Microvessels, a significant component of the tumour microenvironment in colorectal cancer (CRC), have traditionally been assessed in full-face sections. This study aimed to assess the microvessel density (MVD) in CRC tissue microarrays (TMAs) and determined correlations with clinicopathological variables.
Methods
TMAs from 1000 consecutive cases (2008-2014) of CRC from a tertiary centre were immunostained with clinical grade CD34 antibody (1:500 dilution). Stained microvessels and core areas were annotated on digital images (Nanozoomer) and assessed (3D Histech). The MVD was adjudged in luminal, central and peripheral tumour cores as well as adjacent normal, and results correlated to clinicopathological variables (SPSS).
Results
Of 985 assessable cases, 490 had a high overall tumour MVD. The mean tumour MVD was lower than the mean MVD in the adjacent normal area (p

Conference Name 32nd Congress of the ESP and XXXIII International Congress of the IAP
Conference Location Glasgow
Start Date Dec 6, 2020
End Date Dec 8, 2020
Acceptance Date May 27, 2020
Online Publication Date Dec 8, 2020
Publication Date Dec 8, 2020
Deposit Date Aug 27, 2020
Publicly Available Date Dec 8, 2020
Public URL https://nottingham-repository.worktribe.com/output/4854838
Related Public URLs https://www.esp-congress.org/

Files




You might also like



Downloadable Citations