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Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females

Fenton, G.E.; Pollard, Amelia K.; Halliday, D.M.; Mason, Rob; Bredy, Timothy W.; Stevenson, Carl W.

Authors

G.E. Fenton

Amelia K. Pollard

D.M. Halliday

Rob Mason

Timothy W. Bredy



Abstract

Anxiety disorders, such as post-traumatic stress, are more prevalent in women and are characterized by impaired inhibition of learned fear and medial prefrontal cortex (mPFC) dysfunction. Here we examined sex differences in fear extinction and mPFC activity in rats. Females showed more learned fear expression during extinction and its recall, but not fear conditioning. They also showed more spontaneous fear recovery and more contextual fear before extinction and its recall. Moreover, enhanced learned fear expression in females was associated with sustained prelimbic (PL) cortex activity. These results suggest that sex differences in learned fear expression may involve persistent PL activation.

Citation

Fenton, G., Pollard, A. K., Halliday, D., Mason, R., Bredy, T. W., & Stevenson, C. W. (2014). Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females. Learning and Memory, 21(2), https://doi.org/10.1101/lm.033514.113

Journal Article Type Article
Acceptance Date Nov 4, 2013
Publication Date Feb 1, 2014
Deposit Date Jun 30, 2015
Publicly Available Date Jun 30, 2015
Journal Learning and Memory
Print ISSN 1072-0502
Electronic ISSN 1072-0502
Publisher Cold Spring Harbor Laboratory Press
Peer Reviewed Peer Reviewed
Volume 21
Issue 2
DOI https://doi.org/10.1101/lm.033514.113
Public URL http://eprints.nottingham.ac.uk/id/eprint/29248
Publisher URL http://learnmem.cshlp.org/content/21/2/55.long
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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