G.E. Fenton
Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females
Fenton, G.E.; Pollard, Amelia K.; Halliday, D.M.; Mason, Rob; Bredy, Timothy W.; Stevenson, Carl W.
Authors
Amelia K. Pollard
D.M. Halliday
Rob Mason
Timothy W. Bredy
Dr CARL STEVENSON carl.stevenson@nottingham.ac.uk
Associate Professor
Abstract
Anxiety disorders, such as post-traumatic stress, are more prevalent in women and are characterized by impaired inhibition of learned fear and medial prefrontal cortex (mPFC) dysfunction. Here we examined sex differences in fear extinction and mPFC activity in rats. Females showed more learned fear expression during extinction and its recall, but not fear conditioning. They also showed more spontaneous fear recovery and more contextual fear before extinction and its recall. Moreover, enhanced learned fear expression in females was associated with sustained prelimbic (PL) cortex activity. These results suggest that sex differences in learned fear expression may involve persistent PL activation.
Citation
Fenton, G., Pollard, A. K., Halliday, D., Mason, R., Bredy, T. W., & Stevenson, C. W. (2014). Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females. Learning and Memory, 21(2), https://doi.org/10.1101/lm.033514.113
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 4, 2013 |
Publication Date | Feb 1, 2014 |
Deposit Date | Jun 30, 2015 |
Publicly Available Date | Jun 30, 2015 |
Journal | Learning and Memory |
Print ISSN | 1072-0502 |
Electronic ISSN | 1549-5485 |
Publisher | Cold Spring Harbor Laboratory Press |
Peer Reviewed | Peer Reviewed |
Volume | 21 |
Issue | 2 |
DOI | https://doi.org/10.1101/lm.033514.113 |
Public URL | https://nottingham-repository.worktribe.com/output/996948 |
Publisher URL | http://learnmem.cshlp.org/content/21/2/55.long |
Contract Date | Jun 30, 2015 |
Files
Fenton et al 2014 Learn Mem 21;55-60.pdf
(717 Kb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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