Skip to main content

Research Repository

See what's under the surface

Advanced Search

Prescribing practices for intravenous aminoglycosides in UK cystic fibrosis clinics: a questionnaire survey

Smyth, Alan R.; Campbell, Emma L.

Authors

Alan R. Smyth alan.smyth@nottingham.ac.uk

Emma L. Campbell



Abstract

Background: Intravenous aminoglycoside antibiotics are widely used to treat pulmonary infection with Pseudomonas aeruginosa in individuals with cystic fibrosis (CF). Over the last decade evidence has accumulated showing that the choice of aminoglycoside and the dosing regimen may help reduce adverse effects such as nephrotoxicity.
Methods: We undertook an online survey to determine current practice in UK CF Centres.
Results: We received a response from 35/48 (73%) centres. A once daily regimen was used in 30/35 (86%) centres. Around one third had stopped using gentamicin in the last 10 years. In most cases respondents reported changing practice in response to new evidence or evidence based guidelines. Obstacles to introducing evidence based practice were identified both at the level of the CF Centre and the hospital trust.
Conclusions: A once daily aminoglycoside regimen is now used in the majority of UK CF Centres. Tobramycin is first line and many centres have stopped using gentamicin. Obstacles to evidence based practice remain in a minority of centres.

Journal Article Type Article
Publication Date Jul 1, 2014
Journal Journal of Cystic Fibrosis
Print ISSN 1569-1993
Electronic ISSN 1873-5010
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 13
Issue 4
APA6 Citation Smyth, A. R., & Campbell, E. L. (2014). Prescribing practices for intravenous aminoglycosides in UK cystic fibrosis clinics: a questionnaire survey. Journal of Cystic Fibrosis, 13(4), doi:10.1016/j.jcf.2013.11.007
DOI https://doi.org/10.1016/j.jcf.2013.11.007
Keywords Cystic fibrosis; aminoglycosides; nephrotoxicity; once daily
dosing; obstacles to evidence based practice
Publisher URL http://www.sciencedirect.com/science/article/pii/S1569199313001975
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

Files

Smyth JCF 2013 AG survey v4 .pdf (137 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0


Smyth JCF 2013 Table 1 .pdf (42 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





You might also like



Downloadable Citations

;