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Multidimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode 129Xe Hyperpolarizers

Panayiotis, Nikolaou; Coffey, Aaron M.; Ranta, Kaili; Walkup, Laura L.; Gust, Brogan M.; Barlow, Michael J.; Rosen, Matthew S.; Goodson, Boyd M.; Chekmenev, Eduard Y.

Multidimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode 129Xe Hyperpolarizers Thumbnail


Authors

Nikolaou Panayiotis

Aaron M. Coffey

Kaili Ranta

Laura L. Walkup

Brogan M. Gust

Michael J. Barlow

Matthew S. Rosen

Boyd M. Goodson

Eduard Y. Chekmenev



Abstract

We present a systematic, multiparameter study of Rb/129Xe spin-exchange optical pumping (SEOP) in the regimes of high xenon pressure and photon flux using a 3D-printed, clinical-scale stopped-flow hyperpolarizer. In situ NMR detection was used to study the dynamics of 129Xe polarization as a function of SEOP-cell operating temperature, photon flux, and xenon partial pressure to maximize 129Xe polarization (PXe). PXe values of 95 ± 9%, 73 ± 4%, 60 ± 2%, 41 ± 1%, and 31 ± 1% at 275, 515, 1000, 1500, and 2000 Torr Xe partial pressure were achieved. These PXe polarization values were separately validated by ejecting the hyperpolarized 129Xe gas and performing low-field MRI at 47.5 mT. It is shown that PXe in this high-pressure regime can be increased beyond already record levels with higher photon flux and better SEOP thermal management, as well as optimization of the polarization dynamics, pointing the way to further improvements in hyperpolarized 129Xe production efficiency.

Citation

Panayiotis, N., Coffey, A. M., Ranta, K., Walkup, L. L., Gust, B. M., Barlow, M. J., …Chekmenev, E. Y. (2014). Multidimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode 129Xe Hyperpolarizers. Journal of Physical Chemistry B, 118(18), 4809-4816. https://doi.org/10.1021/jp501493k

Journal Article Type Article
Acceptance Date Apr 14, 2014
Online Publication Date Apr 14, 2014
Publication Date Apr 14, 2014
Deposit Date Aug 10, 2018
Publicly Available Date Aug 10, 2018
Print ISSN 1520-6106
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 118
Issue 18
Pages 4809-4816
DOI https://doi.org/10.1021/jp501493k
Public URL https://nottingham-repository.worktribe.com/output/989260
Publisher URL https://pubs.acs.org/doi/abs/10.1021/jp501493k
Contract Date Aug 10, 2018

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