Multidimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode 129Xe Hyperpolarizers

Panayiotis, Nikolaou; Coffey, Aaron M.; Ranta, Kaili; Walkup, Laura L.; Gust, Brogan M.; Barlow, Michael J.; Rosen, Matthew S.; Goodson, Boyd M.; Chekmenev, Eduard Y.

Abstract

We present a systematic, multiparameter study of Rb/129Xe spin-exchange optical pumping (SEOP) in the regimes of high xenon pressure and photon flux using a 3D-printed, clinical-scale stopped-flow hyperpolarizer. In situ NMR detection was used to study the dynamics of 129Xe polarization as a function of SEOP-cell operating temperature, photon flux, and xenon partial pressure to maximize 129Xe polarization (PXe). PXe values of 95 ± 9%, 73 ± 4%, 60 ± 2%, 41 ± 1%, and 31 ± 1% at 275, 515, 1000, 1500, and 2000 Torr Xe partial pressure were achieved. These PXe polarization values were separately validated by ejecting the hyperpolarized 129Xe gas and performing low-field MRI at 47.5 mT. It is shown that PXe in this high-pressure regime can be increased beyond already record levels with higher photon flux and better SEOP thermal management, as well as optimization of the polarization dynamics, pointing the way to further improvements in hyperpolarized 129Xe production efficiency.

Citation

Panayiotis, N., Coffey, A. M., Ranta, K., Walkup, L. L., Gust, B. M., Barlow, M. J., …Chekmenev, E. Y. (2014). Multidimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode 129Xe Hyperpolarizers. Journal of Physical Chemistry B, 118(18), 4809-4816. https://doi.org/10.1021/jp501493k

• Journal Article Type: Article
• Acceptance Date: Apr 14, 2014
• Online Publication Date: Apr 14, 2014
• Publication Date: Apr 14, 2014
• Deposit Date: Aug 10, 2018
• Publicly Available Date: Aug 10, 2018
• Print ISSN: 1520-6106
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 118
• Issue: 18
• Pages: 4809-4816
• DOI: https://doi.org/10.1021/jp501493k
• Publisher URL: https://pubs.acs.org/doi/abs/10.1021/jp501493k