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Spatial Interpolation Enables Normative Data Comparison in Gaze-Contingent Microperimetry

Denniss, Jonathan; Astle, Andrew T.


Jonathan Denniss

Andrew T. Astle


Purpose: To demonstrate methods that enable visual field sensitivities to be compared with normative data without restriction to a fixed test pattern.

Methods: Healthy participants (n = 60, age 19–50) undertook microperimetry (MAIA-2) using 237 spatially dense locations up to 13° eccentricity. Surfaces were fit to the mean, variance, and 5th percentile sensitivities. Goodness-of-fit was assessed by refitting the surfaces 1000 times to the dataset and comparing estimated and measured sensitivities at 50 randomly excluded locations. A leave-one-out method was used to compare individual data with the 5th percentile surface. We also considered cases with unknown fovea location by adding error sampled from the distribution of relative fovea–optic disc positions to the test locations and comparing shifted data to the fixed surface.

Results: Root mean square (RMS) difference between estimated and measured sensitivities were less than 0.5 dB and less than 1.0 dB for the mean and 5th percentile surfaces, respectively. Root mean square differences were greater for the variance surface, median 1.4 dB, range 0.8 to 2.7 dB. Across all participants 3.9% (interquartile range, 1.8–8.9%) of sensitivities fell beneath the 5th percentile surface, close to the expected 5%. Positional error added to the test grid altered the number of locations falling beneath the 5th percentile surface by less than 1.3% in 95% of participants.

Conclusions: Spatial interpolation of normative data enables comparison of sensitivity measurements from varied visual field locations. Conventional indices and probability maps familiar from standard automated perimetry can be produced. These methods may enhance the clinical use of microperimetry, especially in cases of nonfoveal fixation.


Denniss, J., & Astle, A. T. (2016). Spatial Interpolation Enables Normative Data Comparison in Gaze-Contingent Microperimetry. Investigative Ophthalmology & Visual Science, 57(13), 5449-5456.

Journal Article Type Article
Acceptance Date Sep 9, 2016
Online Publication Date Oct 1, 2016
Publication Date Oct 1, 2016
Deposit Date Oct 20, 2016
Publicly Available Date Oct 20, 2016
Journal Investigative Opthalmology & Visual Science
Print ISSN 0146-0404
Electronic ISSN 1552-5783
Publisher Association for Research in Vision and Ophthalmology
Peer Reviewed Peer Reviewed
Volume 57
Issue 13
Pages 5449-5456
Public URL
Publisher URL


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