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Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement

Spuls, Ph.I.; Gerbens, L.A.A.; Simpson, E.; Apfelbacher, C.J.; Chalmers, J.R.; Thomas, K.S.; Prinsen, C.A.C.; Kobyletzki, L.B. von; Singh, J.A.; Williams, Hywel C.; Schmitt, J.

Authors

Ph.I. Spuls

L.A.A. Gerbens

E. Simpson

C.J. Apfelbacher

J.R. Chalmers

C.A.C. Prinsen

L.B. von Kobyletzki

J.A. Singh

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HYWEL WILLIAMS hywel.williams@nottingham.ac.uk
Professor of Dermato-Epidemiology

J. Schmitt



Abstract

Background: The Harmonising Outcome Measures for Eczema (HOME) initiative has defined four core outcome domains for a core outcome set (COS) to be measured in all atopic eczema (AE) trials to ensure cross-trial comparison: clinical signs, symptoms, quality of life and longterm control.
Objectives: The aim of this paper is to report on the consensus process that was used to select the core instrument to consistently assess symptoms in all future AE trials.
Methods: Following the HOME roadmap, two systematic reviews were performed which identified three instruments that had sufficient evidence of validity, reliability, and feasibility to be considered for the final COS.
Results: At the 4th international HOME meeting there was broad consensus among all stakeholders that the Patient-Oriented Eczema Measure (POEM) should be used as the core instrument (87.5% agreed, 9.4% unsure, 3.1% disagreed).
Conclusions: All relevant stakeholders are encouraged to use POEM as the chosen instrument to measure the core domain of symptoms in all future AE clinical trials. Other instruments of interest can be used in addition to POEM.

Citation

Spuls, P., Gerbens, L., Simpson, E., Apfelbacher, C., Chalmers, J., Thomas, K., …Schmitt, J. (2017). Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement. British Journal of Dermatology, 176(4), 979-984. https://doi.org/10.1111/bjd.15179

Journal Article Type Article
Acceptance Date Nov 2, 2016
Online Publication Date Nov 17, 2016
Publication Date Apr 1, 2017
Deposit Date Jan 5, 2017
Publicly Available Date Jan 5, 2017
Journal British Journal of Dermatology
Print ISSN 0007-0963
Electronic ISSN 1365-2133
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 176
Issue 4
Pages 979-984
DOI https://doi.org/10.1111/bjd.15179
Public URL http://eprints.nottingham.ac.uk/id/eprint/39586
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/bjd.15179/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information This is the peer reviewed version of the following article Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement / Ph.I. Spuls, L.A.A. Gerbens, E. Simpson, C.J. Apfelbacher, J.R. Chalmers, K.S. Thomas, C.A.C. Prinsen, L.B. von Kobyletzki, J.A. Singh, H.C. Williams, J. Schmitt and The HOME initiative collaborators, which has been published in final form at http://dx.doi.org/10.1111/bjd.15179. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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