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Models of the cardiac L-type calcium current: A quantitative review

Agrawal, Aditi; Wang, Ken; Polonchuk, Liudmila; Cooper, Jonathan; Hendrix, Maurice; Gavaghan, David J; Gavaghan, David J.; Mirams, Gary R.; Clerx, Michael

Models of the cardiac L-type calcium current: A quantitative review Thumbnail


Authors

Aditi Agrawal

Ken Wang

Liudmila Polonchuk

Jonathan Cooper

Maurice Hendrix

David J Gavaghan

David J. Gavaghan



Abstract

The L-type calcium current ((Formula presented.)) plays a critical role in cardiac electrophysiology, and models of (Formula presented.) are vital tools to predict arrhythmogenicity of drugs and mutations. Five decades of measuring and modeling (Formula presented.) have resulted in several competing theories (encoded in mathematical equations). However, the introduction of new models has not typically been accompanied by a data-driven critical comparison with previous work, so that it is unclear which model is best suited for any particular application. In this review, we describe and compare 73 published mammalian (Formula presented.) models and use simulated experiments to show that there is a large variability in their predictions, which is not substantially diminished when grouping by species or other categories. We provide model code for 60 models, list major data sources, and discuss experimental and modeling work that will be required to reduce this huge list of competing theories and ultimately develop a community consensus model of (Formula presented.). This article is categorized under: Cardiovascular Diseases > Computational Models Cardiovascular Diseases > Molecular and Cellular Physiology.

Journal Article Type Review
Acceptance Date Jul 19, 2022
Online Publication Date Aug 26, 2022
Publication Date Aug 26, 2022
Deposit Date Jul 28, 2022
Publicly Available Date Aug 26, 2022
Journal Wiley Interdisciplinary Reviews: Mechanisms of Disease
Electronic ISSN 2692-9368
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 15
Issue 1
Article Number e1581
DOI https://doi.org/10.1002/wsbm.1581
Keywords Computational Models, Molecular and Cellular Physiology, Advanced Review, Advanced Reviews, calcium channel, cellular electrophysiology, computational model, L‐type calcium current
Public URL https://nottingham-repository.worktribe.com/output/9408031
Publisher URL https://wires.onlinelibrary.wiley.com/doi/10.1002/wsbm.1581

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