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Flow‐induced shear stress and deformation of a core–shell‐structured microcapsule in a microchannel

Hou, Tuo; Ren, Yong; Chan, Yue; Wang, Jing; Yan, Yuying


Tuo Hou

Yong Ren

Yue Chan

Jing Wang

Professor of Thermofluids Engineering


A numerical model was developed and validated to investigate the fluid–structure interactions between fully developed pipe flow and core–shell-structured microcapsule in a microchannel. Different flow rates and microcapsule shell thicknesses were considered. A sixth-order rotational symmetric distribution of von Mises stress over the microcapsule shell can be observed on the microcapsule with a thinner shell configuration, especially at higher flow rate conditions. It is also observed that when being carried along in a fully developed pipe flow, the microcapsule with a thinner shell tends to accumulate stress at a higher rate compared to that with a thicker shell. In general, for the same microcapsule configuration, higher flow velocity would induce a higher stress level over the microcapsule shell. The deformation gradient was used to capture the microcapsule's deformation in the present study. The effect of Young's modulus on the microcapsule shell on the microcapsule deformation was investigated as well. Our findings will shed light on the understanding of the stability of core–shell-structured microcapsule when subjected to flow-induced shear stress in a microfluidic system, enabling a more exquisite control over the breakup dynamics of drug-loaded microcapsule for biomedical applications.


Hou, T., Ren, Y., Chan, Y., Wang, J., & Yan, Y. (2022). Flow‐induced shear stress and deformation of a core–shell‐structured microcapsule in a microchannel. ELECTROPHORESIS,

Journal Article Type Article
Acceptance Date Jun 20, 2022
Online Publication Date Jul 14, 2022
Publication Date Jul 14, 2022
Deposit Date Jul 25, 2022
Publicly Available Date Jul 15, 2023
Print ISSN 0173-0835
Electronic ISSN 1522-2683
Publisher Wiley-VCH Verlag
Peer Reviewed Peer Reviewed
Keywords Clinical Biochemistry; Biochemistry; Analytical Chemistry
Public URL
Publisher URL
Additional Information This is the peer reviewed version of the following article: Hou, T, Ren, Y, Chan, Y, Wang, J, Yan, Y. Flow-induced shear stress and deformation of a core–shell-structured microcapsule in a microchannel. Electrophoresis. 2022, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.