Dr CHITRA JOSEPH CHITRA.JOSEPH@NOTTINGHAM.AC.UK
Research Fellow
Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes
Joseph, Chitra; Macnamara, Olivia; Craze, Madeleine; Russell, Roslin; Provenzano, Elena; Nolan, Christopher C.; Diez-Rodriguez, Maria; Sonbul, Sultan N.; Aleskandarany, Mohammed A.; Green, Andrew R.; Rakha, Emad A.; Ellis, Ian O.; Mukherjee, Abhik
Authors
Olivia Macnamara
Madeleine Craze
Roslin Russell
Elena Provenzano
Christopher C. Nolan
Maria Diez-Rodriguez
Sultan N. Sonbul
Mohammed A. Aleskandarany
ANDREW GREEN ANDREW.GREEN@NOTTINGHAM.AC.UK
Associate Professor
EMAD RAKHA Emad.Rakha@nottingham.ac.uk
Professor of Breast Cancer Pathology
Professor IAN ELLIS IAN.ELLIS@NOTTINGHAM.AC.UK
Professor of Cancer Pathology
Dr ABHIK MUKHERJEE ABHIK.MUKHERJEE1@NOTTINGHAM.AC.UK
Clinical Associate Professor
Abstract
Background: Mediator complex (MED) proteins have a key role in transcriptional regulation, some interacting with the oestrogen receptor (ER). Interrogation of the METABRIC cohort suggested that MED7 may regulate lymphovascular invasion (LVI). Thus MED7 expression was assessed in large breast cancer (BC) cohorts to determine clinicopathological significance.
Methods: MED7 gene expression was investigated in the METABRIC cohort (n?=?1980) and externally validated using bc-GenExMiner v4.0. Immunohistochemical expression was assessed in the Nottingham primary BC series (n?=?1280). Associations with clinicopathological variables and patient outcome were evaluated.
Results: High MED7 mRNA and protein expression was associated with good prognostic factors: low grade, smaller tumour size, good NPI, positive hormone receptor status (p?
Citation
Joseph, C., Macnamara, O., Craze, M., Russell, R., Provenzano, E., Nolan, C. C., …Mukherjee, A. (in press). Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes. British Journal of Cancer, https://doi.org/10.1038/s41416-018-0041-x
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 30, 2018 |
Online Publication Date | Mar 28, 2018 |
Deposit Date | Apr 16, 2018 |
Publicly Available Date | Mar 29, 2019 |
Journal | British Journal of Cancer |
Print ISSN | 0007-0920 |
Electronic ISSN | 0007-0920 |
Publisher | Cancer Research UK |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1038/s41416-018-0041-x |
Public URL | https://nottingham-repository.worktribe.com/output/921886 |
Publisher URL | https://www.nature.com/articles/s41416-018-0041-x |
Files
Supplimentry Figure 2-Re-submission___.pdf
(229 Kb)
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MED7 manuscript-AAM.pdf
(844 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0
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