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Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes

Joseph, Chitra; Macnamara, Olivia; Craze, Madeleine; Russell, Roslin; Provenzano, Elena; Nolan, Christopher C.; Diez-Rodriguez, Maria; Sonbul, Sultan N.; Aleskandarany, Mohammed A.; Green, Andrew R.; Rakha, Emad A.; Ellis, Ian O.; Mukherjee, Abhik

Authors

Chitra Joseph

Olivia Macnamara

Madeleine Craze

Roslin Russell

Elena Provenzano

Christopher C. Nolan

Maria Diez-Rodriguez

Sultan N. Sonbul

Mohammed A. Aleskandarany

Andrew R. Green

Emad A. Rakha

Abhik Mukherjee



Abstract

Background: Mediator complex (MED) proteins have a key role in transcriptional regulation, some interacting with the oestrogen receptor (ER). Interrogation of the METABRIC cohort suggested that MED7 may regulate lymphovascular invasion (LVI). Thus MED7 expression was assessed in large breast cancer (BC) cohorts to determine clinicopathological significance.
Methods: MED7 gene expression was investigated in the METABRIC cohort (n = 1980) and externally validated using bc-GenExMiner v4.0. Immunohistochemical expression was assessed in the Nottingham primary BC series (n = 1280). Associations with clinicopathological variables and patient outcome were evaluated.
Results: High MED7 mRNA and protein expression was associated with good prognostic factors: low grade, smaller tumour size, good NPI, positive hormone receptor status (p 

Journal Article Type Article
Journal British Journal of Cancer
Print ISSN 0007-0920
Electronic ISSN 0007-0920
Publisher Cancer Research UK
Peer Reviewed Peer Reviewed
APA6 Citation Joseph, C., Macnamara, O., Craze, M., Russell, R., Provenzano, E., Nolan, C. C., …Mukherjee, A. (in press). Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes. British Journal of Cancer, doi:10.1038/s41416-018-0041-x
DOI https://doi.org/10.1038/s41416-018-0041-x
Publisher URL https://www.nature.com/articles/s41416-018-0041-x
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0








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