Ashley Ramsawhook
Wilms' Tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives
Ramsawhook, Ashley; Ruzov, Alexey; Coyle, Beth
Abstract
The patterns of 5-methylcytosine (5mC) and its oxidized derivatives, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine (5caC) are reportedly altered in a range of cancers. Likewise, Wilms’ Tumor protein 1 (WT1), a transcription factor essential for urogenital, epicardium, and kidney development exhibits aberrant expression in multiple tumors. Interestingly, WT1 directly interacts with TET proteins that catalyze the enzymatic oxidation of 5mC and exhibits high affinity for 5caC-containing DNA substrates in vitro. Here we review recent developments in the fields of Tet-dependent 5mC oxidation and WT1 biology and explore potential perspectives for studying the interplay between TETs and WT1 in brain tumors.
Citation
Ramsawhook, A., Ruzov, A., & Coyle, B. (2018). Wilms' Tumor protein 1 and enzymatic oxidation of 5-methylcytosine in brain tumors: potential perspectives. Frontiers in Cell and Developmental Biology, 6, https://doi.org/10.3389/fcell.2018.00026
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Mar 5, 2018 |
| Publication Date | Mar 22, 2018 |
| Deposit Date | Jul 27, 2018 |
| Publicly Available Date | Jul 27, 2018 |
| Journal | Frontiers in Cell and Developmental Biology |
| Electronic ISSN | 2296-634X |
| Publisher | Frontiers Media |
| Peer Reviewed | Peer Reviewed |
| Volume | 6 |
| DOI | https://doi.org/10.3389/fcell.2018.00026 |
| Keywords | Wilms’ Tumor 1, DNA demethylation, epigenetics, brain tumors, glioblastoma, ependymoma, medullobastoma, TET proteins |
| Public URL | https://nottingham-repository.worktribe.com/output/921143 |
| Publisher URL | https://www.frontiersin.org/articles/10.3389/fcell.2018.00026/full |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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