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The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours

El Ansari, Rokaya; Craze, Madeleine L.; Miligy, Islam; Diez-Rodriguez, Maria; Nolan, Christopher C.; Ellis, Ian O.; Rakha, Emad; Green, Andrew R.

The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours Thumbnail


Authors

Rokaya El Ansari

Madeleine L. Craze

Islam Miligy

Maria Diez-Rodriguez

Christopher C. Nolan

EMAD RAKHA Emad.Rakha@nottingham.ac.uk
Professor of Breast Cancer Pathology



Abstract

Background: Breast cancer (BC) is a heterogeneous disease characterised by variant biology and patient outcome. The amino acid transporter, SLC7A5, plays a role in BC although its impact on patient outcome in different BC subtypes remains to be validated. This study aimed to determine whether the clinicopathological and prognostic value of SLC7A5 is different within the molecular classes of BC.
Methods: SLC7A5 was assessed at the genomic, using METABRIC data (n=1,980), and proteomic, using immunohistochemistry and TMA (n= 2664; 1,110 training and 1,554 validation sets), levels in well-characterised primary BC cohorts. SLC7A5 expression was correlated with clinicopathological and biological parameters, molecular subtypes, and patient outcome.
Results: SLC7A5 mRNA and protein expression were strongly correlated with larger tumour size, and higher grade. High expression was observed in triple negative (TN), HER2+, and luminal B subtypes. SLC7A5 mRNA and protein expression was significantly associated with the expression of the key regulator of tumour cell metabolism c-MYC, specifically in Luminal B tumours only (p=0.001). High expression of SLC7A5 mRNA and protein was associated with poor patient outcome (p

Citation

El Ansari, R., Craze, M. L., Miligy, I., Diez-Rodriguez, M., Nolan, C. C., Ellis, I. O., …Green, A. R. (in press). The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours. Breast Cancer Research, 20(21), https://doi.org/10.1186/s13058-018-0946-6

Journal Article Type Article
Acceptance Date Feb 26, 2018
Online Publication Date Mar 22, 2018
Deposit Date Feb 23, 2018
Publicly Available Date Mar 29, 2024
Journal Breast Cancer Research
Print ISSN 1465-5411
Electronic ISSN 1465-542X
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 20
Issue 21
DOI https://doi.org/10.1186/s13058-018-0946-6
Keywords SLC7A5; breast cancer; prognosis
Public URL https://nottingham-repository.worktribe.com/output/921060
Publisher URL https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-018-0946-6

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