JANE GROVE jane.grove@nottingham.ac.uk
Assistant Professor
Analysis of genotyping for predicting liver injury marker, Procollagen III in persons at risk of non-alcoholic fatty liver disease
Grove, Jane I.; Thiagarajan, Prarthana; Astbury, Stuart; Harris, Rebecca; Delahooke, Toby; Guha, Indra Neil; Aithal, Guruprasad P.
Authors
Prarthana Thiagarajan
STUART ASTBURY STUART.ASTBURY@NOTTINGHAM.AC.UK
Research Fellow
Rebecca Harris
Toby Delahooke
NEIL GUHA neil.guha@nottingham.ac.uk
Professor of Hepatology
GURUPRASAD AITHAL Guru.Aithal@nottingham.ac.uk
Professor of Hepatology
Abstract
Background & Aims
Chronic liver disease presents a major global public health challenge. Stratification of asymptomatic, at-risk patients in primary care using non-invasive methods has the potential to address this by identifying those likely to progress. We therefore evaluated variant alleles at loci associated with non-alcoholic fatty liver disease (NAFLD) as genetic determinants of substantial liver injury in patients with disease risk factors.
Methods
Levels of serum procollagen III (PIIINP), an established fibrosis and steatohepatitis marker, were determined in 467 people who had type 2 diabetes and/or BMI>27.3 (identified from registration with general practitioners) in this observational cross-sectional study. Patients were genotyped for characterised risk alleles in PNPLA3 (rs738409), GCKR (rs1260326) and TM6SF2 (rs58542926) and associations with PIIINP assessed.
Results
The risk alleles in PNPLA3, GCKR or TM6SF2 were not found to be individually associated with the presence of a disease risk factor and were not significantly more common in patients with raised serum PIIINP. The prevalence of possession of both PNPLA3 and GCKR variant alleles combined was significantly higher in at-risk patients with clinically significant liver disease indicated by serum PIIINP above 11 ng/ml (P=0.014).
Conclusions
Genotyping therefore has limited value for predicting severe liver disease in at-risk individuals identified in a community setting.
Citation
Grove, J. I., Thiagarajan, P., Astbury, S., Harris, R., Delahooke, T., Guha, I. N., & Aithal, G. P. (2018). Analysis of genotyping for predicting liver injury marker, Procollagen III in persons at risk of non-alcoholic fatty liver disease. Liver International, 38(10), 1832-1838. https://doi.org/10.1111/liv.13733
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 21, 2018 |
Online Publication Date | Mar 1, 2018 |
Publication Date | 2018-10 |
Deposit Date | Mar 9, 2018 |
Publicly Available Date | Mar 29, 2024 |
Journal | Liver International |
Print ISSN | 1478-3223 |
Electronic ISSN | 1478-3231 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 38 |
Issue | 10 |
Pages | 1832-1838 |
DOI | https://doi.org/10.1111/liv.13733 |
Keywords | PNPLA3, GCKR, TM6SF2, NAFLD |
Public URL | https://nottingham-repository.worktribe.com/output/918179 |
Publisher URL | http://onlinelibrary.wiley.com/doi/10.1111/liv.13733/abstract |
Files
FINAL upload liv int geno manuscript 220218.pdf
(573 Kb)
PDF
You might also like
Integrins as a drug target in liver fibrosis
(2022)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: digital-library-support@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search