Cannabinoid ligands, receptors and enzymes: pharmacological tools and therapeutic potential
Hourani, Wafa; Alexander, Stephen P. H.
Stephen P. H. Alexander
Endocannabinoids have been identified to have roles in numerous physiological and pathological processes. Largely due to the association of the effects of Cannabis administration on mental states, the CNS impact of the endocannabinoid system has been the most intensively studied. Here, we provide a brief summary of the endocannabinoid system, comprising the receptors and the multiple endogenous lipid derivatives which activate them, as well as the enzymes which control the levels of these lipid derivatives. We identify pharmacological tools which may be used to interrogate the endocannabinoid system, as well as current and future options to exploit the system in the clinic.
|Journal Article Type||Review|
|Publication Date||Jun 19, 2018|
|Journal||Brain and Neuroscience Advances|
|Publisher||SAGE Publications (UK and US)|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Hourani, W., & Alexander, S. P. H. (2018). Cannabinoid ligands, receptors and enzymes: pharmacological tools and therapeutic potential. Brain and Neuroscience Advances, 2, doi:10.1177/2398212818783908. ISSN 2398-2128|