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Cannabinoid ligands, receptors and enzymes: pharmacological tools and therapeutic potential

Hourani, Wafa; Alexander, Stephen P. H.

Authors

Wafa Hourani

Stephen P. H. Alexander



Abstract

Endocannabinoids have been identified to have roles in numerous physiological and pathological processes. Largely due to the association of the effects of Cannabis administration on mental states, the CNS impact of the endocannabinoid system has been the most intensively studied. Here, we provide a brief summary of the endocannabinoid system, comprising the receptors and the multiple endogenous lipid derivatives which activate them, as well as the enzymes which control the levels of these lipid derivatives. We identify pharmacological tools which may be used to interrogate the endocannabinoid system, as well as current and future options to exploit the system in the clinic.

Journal Article Type Review
Publication Date Jun 19, 2018
Journal Brain and Neuroscience Advances
Electronic ISSN 2398-2128
Publisher SAGE Publications (UK and US)
Peer Reviewed Peer Reviewed
Volume 2
Pages 239821281878390
APA6 Citation Hourani, W., & Alexander, S. P. H. (2018). Cannabinoid ligands, receptors and enzymes: pharmacological tools and therapeutic potential. Brain and Neuroscience Advances, 2, doi:10.1177/2398212818783908. ISSN 2398-2128
DOI https://doi.org/10.1177/2398212818783908
Publisher URL http://journals.sagepub.com/doi/10.1177/2398212818783908
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