A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis

Gao, Yi-Qun; Chen, Jiu-Geng; Chen, Zi-Ru; An, Dong; Lv, Qiao-Yan; Han, Mei-Ling; Wang, Ya-Ling; Salt, David E.; Chao, Dai-Yin

Abstract

Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported that a choline transporter gene, CTL1, controls ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodesmata (PD) development, as well as the transport of some ion transporters. Map-based cloning studies revealed that CTL1 mutations alter the ion profile of Arabidopsis thaliana. We found that the phenotypes associated with these mutations are caused by a combination of PD defects and ion transporter misregulation. We also established that CTL1 is involved in regulating vesicle trafficking and is thus required for the trafficking of proteins essential for ion transport and PD development. Characterizing choline transporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but also vesicle trafficking in general.

Citation

Gao, Y.-Q., Chen, J.-G., Chen, Z.-R., An, D., Lv, Q.-Y., Han, M.-L., …Chao, D.-Y. (2017). A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis. PLoS Biology, 15(12), Article e2002978. https://doi.org/10.1371/journal.pbio.2002978

• Journal Article Type: Article
• Acceptance Date: Nov 21, 2017
• Publication Date: Dec 28, 2017
• Deposit Date: Jan 11, 2018
• Publicly Available Date: Jan 11, 2018
• Journal: PLoS Biology
• Print ISSN: 1544-9173
• Electronic ISSN: 1545-7885
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 15
• Issue: 12
• Article Number: e2002978
• DOI: https://doi.org/10.1371/journal.pbio.2002978
• Public URL: https://nottingham-repository.worktribe.com/output/901814
• Publisher URL: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002978
• Contract Date: Jan 11, 2018