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A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis

Gao, Yi-Qun; Chen, Jiu-Geng; Chen, Zi-Ru; An, Dong; Lv, Qiao-Yan; Han, Mei-Ling; Wang, Ya-Ling; Salt, David E.; Chao, Dai-Yin

A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis Thumbnail


Authors

Yi-Qun Gao

Jiu-Geng Chen

Zi-Ru Chen

Dong An

Qiao-Yan Lv

Mei-Ling Han

Ya-Ling Wang

David E. Salt

Dai-Yin Chao



Abstract

Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported that a choline transporter gene, CTL1, controls ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodesmata (PD) development, as well as the transport of some ion transporters. Map-based cloning studies revealed that CTL1 mutations alter the ion profile of Arabidopsis thaliana. We found that the phenotypes associated with these mutations are caused by a combination of PD defects and ion transporter misregulation. We also established that CTL1 is involved in regulating vesicle trafficking and is thus required for the trafficking of proteins essential for ion transport and PD development. Characterizing choline transporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but also vesicle trafficking in general.

Journal Article Type Article
Acceptance Date Nov 21, 2017
Publication Date Dec 28, 2017
Deposit Date Jan 11, 2018
Publicly Available Date Jan 11, 2018
Journal PLoS Biology
Print ISSN 1544-9173
Electronic ISSN 1545-7885
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 15
Issue 12
Article Number e2002978
DOI https://doi.org/10.1371/journal.pbio.2002978
Public URL https://nottingham-repository.worktribe.com/output/901814
Publisher URL http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002978

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