Gemma C. Geary
Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery
Geary, Gemma C.; Nortcliffe, Andrew; Pearce, Christopher A.; Hamza, Daniel; Jones, Geraint; Moody, Christopher J.
Christopher A. Pearce
Christopher J. Moody
A spirocyclic, sp3-atom rich oxetane-containing scaffold was synthesised in just two steps via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be undertaken on a 40 g scale allowing the preparation of 419 lead-like compounds based on the scaffold for the European Lead Factory.
|Journal Article Type||Article|
|Journal||Bioorganic & Medicinal Chemistry|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Geary, G. C., Nortcliffe, A., Pearce, C. A., Hamza, D., Jones, G., & Moody, C. J. (in press). Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery. Bioorganic and Medicinal Chemistry, doi:10.1016/j.bmc.2017.12.012|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0|
Chris Moody Densely functionalised spirocclic.pdf
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0
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