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The Nottingham Fatigue After Stroke (NotFAST) Study: results from follow-up six months after stroke

Hawkins, Louise; Lincoln, Nadina; Sprigg, Nikola; Ward, Nick; Mistri, Amit; Tyrrell, Pippa; Worthington, Esme; Drummond, Avril E.R.


Louise Hawkins

Nadina Lincoln

Nikola Sprigg

Nick Ward

Amit Mistri

Pippa Tyrrell

Esme Worthington

Avril E.R. Drummond


Background: Post-stroke fatigue is common and disabling.
Objectives: The aim of NotFAST was to examine factors associated with fatigue in stroke 3 survivors without depression, six months after stroke.
Methods: Participants were recruited from four UK stroke units. Those with high levels of 5 depressive symptoms (score ≥7 on Brief Assessment Schedule Depression Cards) or aphasia were excluded. Follow-up assessment was conducted at six months after stroke. They were assessed on the Fatigue Severity Scale, Rivermead Mobility Index, Nottingham Extended Activities of Daily Living scale, Barthel Index, Beck Anxiety Index, Brief Assessment Schedule Depression Cards, Impact of Event Scale-Revised, and Sleep Hygiene Index.
Results: Of the 371 participants recruited, 263 (71%) were contacted at six months after stroke and 213 (57%) returned questionnaires. Approximately half (n=109, 51%) reported fatigue at six months. Of those reporting fatigue initially (n=88), 61 (69%) continued to report fatigue. ‘De novo’ (new) fatigue was reported by 48 (38%) of those not fatigued initially. Lower Nottingham Extended Activities of Daily Living scores and higher Beck Anxiety Index scores were independently associated with fatigue at six months.
Conclusions: Half the stroke survivors reported fatigue at six months post-stroke. Reduced independence in activities of daily living and higher anxiety levels were associated with the level of fatigue. Persistent and delayed onset fatigue may affect independence and participation in rehabilitation, and these findings should be used to inform the development of appropriate interventions.

Journal Article Type Article
Journal Topics in Stroke Rehabilitation
Print ISSN 1074-9357
Electronic ISSN 1945-5119
Publisher Taylor & Francis
Peer Reviewed Peer Reviewed
Volume 24
Issue 8
APA6 Citation Hawkins, L., Lincoln, N., Sprigg, N., Ward, N., Mistri, A., Tyrrell, P., …Drummond, A. E. (in press). The Nottingham Fatigue After Stroke (NotFAST) Study: results from follow-up six months after stroke. Topics in Stroke Rehabilitation, 24(8), doi:10.1080/10749357.2017.1368912
Keywords CVA; fatigue; follow-up; mood; rehabilitation; stroke; anxiety
Publisher URL
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is an Accepted Manuscript of an article published by Taylor & Francis in Topics in Stroke Rehabilitation on 11/09/2017, available online: http://www.tandfonline....0/10749357.2017.1368912