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Phenotypic characterization of breast cancer: the role of CDC42

Chrysanthou, Eleni; Gorringe, Kylie L.; Joseph, Chitra; Craze, Madeleine L.; Nolan, Christopher C.; Diez-Rodriguez, Maria; Green, Andrew R.; Rakha, Emad A.; Ellis, Ian O.; Mukherjee, Abhik

Authors

Eleni Chrysanthou

Kylie L. Gorringe

Chitra Joseph

Madeleine L. Craze

Christopher C. Nolan

Maria Diez-Rodriguez

Andrew R. Green

Emad A. Rakha

Ian O. Ellis

Abhik Mukherjee



Abstract

Purpose: The molecular landscape of breast cancer (BC), especially of the Luminal A subtype, remains to be fully delineated. Transcriptomic data shows that Luminal A tumours are enriched for aberrant expression of genes in the cell division control 42 homolog (CDC42) pathway. This study aims to investigate protein expression of CDC42 in BC and assess its clinicopathological significance.
Methods: Expression of CDC42 protein was examined by immunohistochemistry on tissue microarrays in a well characterised cohort of 895 early stage (I-IIIa) primary invasive BCs.
Results: CDC42 expression was observed in both the cytoplasm and nucleus of BC cells. High nuclear CDC42 expression demonstrated a significant correlation with ER positive, low-grade tumours and was more common in the lobular histological subtype (all p

Journal Article Type Article
Publication Date Jul 31, 2017
Journal Breast Cancer Research and Treatment
Print ISSN 0167-6806
Electronic ISSN 1573-7217
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 164
Issue 2
APA6 Citation Chrysanthou, E., Gorringe, K. L., Joseph, C., Craze, M. L., Nolan, C. C., Diez-Rodriguez, M., …Mukherjee, A. (2017). Phenotypic characterization of breast cancer: the role of CDC42. Breast Cancer Research and Treatment, 164(2), https://doi.org/10.1007/s10549-017-4267-8
DOI https://doi.org/10.1007/s10549-017-4267-8
Keywords CDC42, Immunohistochemistry, Luminal breast cancer, prognosis
Publisher URL https://link.springer.com/article/10.1007%2Fs10549-017-4267-8
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0







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