Skip to main content

Research Repository

See what's under the surface

Advanced Search

Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster

Lewis, Jo E.; Samms, Ricardo J.; Cooper, Scott; Luckett, Jeni C.; Perkins, Alan C.; Adams, Andrew C.; Tsintzas, Kostas; Ebling, Francis J.P.

Authors

Jo E. Lewis

Ricardo J. Samms

Scott Cooper

Jeni C. Luckett

Alan C. Perkins

Andrew C. Adams

Kostas Tsintzas

Francis J.P. Ebling fran.ebling@nottingham.ac.uk



Abstract

FGF21 exerts profound metabolic effects in Siberian hamsters exposed to long day (LD) photoperiods that increase appetite and adiposity, however these effects are attenuated in short day (SD) animals that display hypophagia and reduced adiposity. The aim of this study was to investigate whether the beneficial effects of a novel mimetic of FGF21 in the LD state are a consequence of increased adiposity or of the central photoperiodic state. This was achieved by investigating effects of FGF21 in aged hamsters, which is associated with reduced adiposity. In LD hamsters with increased adiposity, FGF21 lowered body weight as a result of both reduced daily food intake and increased caloric expenditure, driven by an increase in whole-body fat oxidation. However, in LD animals with reduced adiposity, the effect of FGF21 on body weight, caloric intake and fat oxidation were significantly attenuated or absent when compared to those with increased adiposity. These attenuated/absent effects were underpinned by the inability of FGF21 to increase the expression of key thermogenic genes in interscapular and visceral WAT. Our study demonstrates the efficacy of a novel FGF21 mimetic in hamsters, but reveals attenuated effects in the animal model where adiposity is reduced naturally independent of photoperiod.

Journal Article Type Article
Journal Scientific Reports
Print ISSN 2045-2322
Electronic ISSN 2045-2322
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 7
Issue 1
Article Number 4238
APA6 Citation Lewis, J. E., Samms, R. J., Cooper, S., Luckett, J. C., Perkins, A. C., Adams, A. C., …Ebling, F. J. (in press). Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster. Scientific Reports, 7(1), https://doi.org/10.1038/s41598-017-03607-x
DOI https://doi.org/10.1038/s41598-017-03607-x
Keywords Fat metabolism, Metabolic syndrome
Publisher URL https://doi.org/10.1038/s41598-017-03607-x
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

Files

Hamster nature.pdf (2 Mb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





You might also like



Downloadable Citations

;