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Elevated expression of STK3 mRNA and protein is associated with poor outcome in invasive breast cancer

Ojiegbe, S.; Joseph, C.; Provenzano, E.; Caldas, C.; Nolan, C.; Green, A.R.; Rakha, E.; Ellis, I.O.; Mukherjee, A.

Authors

S. Ojiegbe

C. Joseph

E. Provenzano

C. Caldas

C. Nolan

A.R. Green andrew.green@nottingham.ac.uk

E. Rakha

A. Mukherjee



Abstract

Purpose of the study: The mammalian sterile 20-like kinase (MST2/STK3) and its close homologue MST1(STK4) are members of the germinal centre kinase group II (GCK II) family of mitogen-activated protein kinases (MAPK). High STK3 expression is known to be correlated with poor prognosis in various cancers playing a role in cell migration and invasion. This study aimed to determine correlations of STK3 expression with clinicopathological variables in BCs.
Methods: STK3 mRNA expression was investigated in the METABRIC BC cohort (n=1980) and externally validated using online BC expression datasets [bc-GenExMiner v4.0]. STK3 protein expression was studied in a well characterised series of primary invasive BCs (n=1024) using immunohistochemistry including correlations with clinicopathological parameters, other biomarkers and patient outcome.
Results: Copy number (CN) gain of STK3 was correlated with adverse prognostic features: higher grade and poor NPI (p

Publication Date Jun 20, 2017
Peer Reviewed Peer Reviewed
Article Number O21
APA6 Citation Ojiegbe, S., Joseph, C., Provenzano, E., Caldas, C., Nolan, C., Green, A., …Mukherjee, A. (2017). Elevated expression of STK3 mRNA and protein is associated with poor outcome in invasive breast cancer
Publisher URL https://www.path.org.uk/wp-content/uploads/2017/06/BP2017-PLENARY-ORAL-ABSTRACTS-05.06.17.pdf
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf







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