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Cell division cycle 25C (CDC25C) expression confers poor prognosis in invasive breast cancer

Ojiegbe, S.; Joseph, C.; Provenzano, E.; Caldas, C.; Nolan, C.; Green, A.R.; Rakha, E.; Ellis, I.O.; Mukherjee, A.

Authors

S. Ojiegbe

C. Joseph

E. Provenzano

C. Caldas

C. Nolan

A.R. Green

E. Rakha

I.O. Ellis

A. Mukherjee abhik.mukherjee1@nottingham.ac.uk



Abstract

Background: CDC25C, belonging to the Cdc25 phosphatase family, plays a major role in cell cycle control, impacting on DNA repair and apoptosis. It has been shown that poor prognosis/copy number high Luminal A breast cancers (BCs) are enriched for the Aurora kinase pathway including CDC25C leading to CDK1 activation (Ciriello et al, Breast Cancer Research Treatment, 2013:409). This study examined the associations of CDC25C with clinicopathological and molecular features in BCs including the low grade ER positive cohort.
Methodology: CDC25C mRNA expression was studied in the METABRIC BC cohort (n=1980) and externally validated using online expression datasets [bc-GenExMiner v4.0]. CDC25C protein expression level was assessed immunohistochemically on a large annotated series of BC (n= 1330) and correlations made with clinicopathological parameters and patient outcome.
Results: High CDC25C expression was significantly associated with poor prognostic factors including high grade, large tumour size, medullary like tumours, poorer NPI, ER-/PR- Her2+ status (p

Publication Date Jun 20, 2017
Peer Reviewed Peer Reviewed
APA6 Citation Ojiegbe, S., Joseph, C., Provenzano, E., Caldas, C., Nolan, C., Green, A., …Mukherjee, A. (2017). Cell division cycle 25C (CDC25C) expression confers poor prognosis in invasive breast cancer
Publisher URL https://www.path.org.uk/wp-content/uploads/2017/06/BP2017-PLENARY-ORAL-ABSTRACTS-05.06.17.pdf
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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