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FOXP1 expression correlates with better prognosis in invasive breast cancer including the ER-positive luminal subtype

Joseph, C.; Craze, Madeleine L.; Nolan, C.C.; Diez-Rodriguez, Maria; Green, Andrew R.; Rakha, Emad; Ellis, Ian O.; Mukherjee, A.

Authors

C. Joseph

Madeleine L. Craze

C.C. Nolan

Maria Diez-Rodriguez

Andrew R. Green

Emad Rakha

Ian O. Ellis

A. Mukherjee



Abstract

Background: Fork head box P1 (FOXP1) is a FOX family transcription factor influencing ERα;-regulated transcription by interaction with the ERα; related pioneer factor FOXA1. Altered FOXP1 expression is seen in breast and prostate cancers. This study investigated FOXP1 at the protein level in breast cancer (BC) and examined associations with clinicopathological and molecular features.
Methods: FOXP1 mRNA expression was investigated in the METABRIC BC cohort (n=1980) and validated using online expression datasets [bc-GenExMiner v4.0]. Protein expression was studied in a well characterised BC primary series (n=621) using immunohistochemistry and correlations made with clinicopathological parameters and outcome.
Results: High FOXP1 mRNA and protein expression was significantly associated with low grade, low NPI, positive ER/PR status, lobular BCs, low Ki67 and negative Her2 status (p

Publication Date Jun 20, 2017
Peer Reviewed Peer Reviewed
Article Number O25
APA6 Citation Joseph, C., Craze, M. L., Nolan, C., Diez-Rodriguez, M., Green, A. R., Rakha, E., …Mukherjee, A. (2017). FOXP1 expression correlates with better prognosis in invasive breast cancer including the ER-positive luminal subtype
Publisher URL https://www.path.org.uk/wp-content/uploads/2017/06/BP2017-PLENARY-ORAL-ABSTRACTS-05.06.17.pdf
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf







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