FOXP1 expression correlates with better prognosis in invasive breast cancer including the ER-positive luminal subtype

Joseph, C.; Craze, Madeleine L.; Nolan, C.C.; Diez-Rodriguez, Maria; Green, Andrew R.; Rakha, Emad; Ellis, Ian O.; Mukherjee, A.

Abstract

Background: Fork head box P1 (FOXP1) is a FOX family transcription factor influencing ERα;-regulated transcription by interaction with the ERα; related pioneer factor FOXA1. Altered FOXP1 expression is seen in breast and prostate cancers. This study investigated FOXP1 at the protein level in breast cancer (BC) and examined associations with clinicopathological and molecular features.
Methods: FOXP1 mRNA expression was investigated in the METABRIC BC cohort (n=1980) and validated using online expression datasets [bc-GenExMiner v4.0]. Protein expression was studied in a well characterised BC primary series (n=621) using immunohistochemistry and correlations made with clinicopathological parameters and outcome.
Results: High FOXP1 mRNA and protein expression was significantly associated with low grade, low NPI, positive ER/PR status, lobular BCs, low Ki67 and negative Her2 status (p

Citation

Joseph, C., Craze, M. L., Nolan, C., Diez-Rodriguez, M., Green, A. R., Rakha, E., …Mukherjee, A. (2017). FOXP1 expression correlates with better prognosis in invasive breast cancer including the ER-positive luminal subtype.

• Conference Name: Belfast Pathology 2017: 10th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland
• End Date: Jun 23, 2017
• Acceptance Date: Apr 7, 2017
• Publication Date: Jun 20, 2017
• Deposit Date: Jul 7, 2017
• Publicly Available Date: Jul 7, 2017
• Peer Reviewed: Peer Reviewed
• Article Number: O25
• Public URL: https://nottingham-repository.worktribe.com/output/867281
• Publisher URL: https://www.path.org.uk/wp-content/uploads/2017/06/BP2017-PLENARY-ORAL-ABSTRACTS-05.06.17.pdf