Skip to main content

Research Repository

See what's under the surface

Advanced Search

Continuous niobium phosphate catalysed Skraup reaction for quinoline synthesis from solketal

Jin, Jing; Guidi, Sandro; Amara, Zacharias; Selva, Maurizio; George, Michael W.; Poliakoff, Martyn

Authors

Jing Jin JIN JING

Sandro Guidi sandro guidi

Zacharias Amara AMARA Zacharias

Maurizio Selva Selva Maurizio

Michael W. George mike.george@nottingham.ac.uk

Martyn Poliakoff



Abstract

Solketal is derived from the reaction of acetone with glycerol, a by-product product of the biodiesel industry. We report here the continuous reaction of solketal with anilines over a solid acid niobium phosphate (NbP), for the continuous generation of quinolines in the the well-established Skraup reaction. This study shows that NbP can catalyse all stages of this multistep reaction at 250 °C and 10 MPa pressure, with a selectivity for quinoline of up to 60%. We found that the catalyst eventually deactivates, most probably via a combination of coking and reduction processes but nevertheless we show the promise of this approach. We demonstrated here the application of our approach to synthesize both mono- and bis-quinolines from the commodity chemical, 4,4’-methylenedianiline.

Journal Article Type Article
Publication Date Apr 28, 2017
Journal Green Chemistry
Print ISSN 1463-9262
Electronic ISSN 1463-9262
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 19
APA6 Citation Jin, J., Guidi, S., Amara, Z., Selva, M., George, M. W., & Poliakoff, M. (2017). Continuous niobium phosphate catalysed Skraup reaction for quinoline synthesis from solketal. Green Chemistry, 19, doi:10.1039/C6GC03140D
DOI https://doi.org/10.1039/C6GC03140D
Keywords Niobium phosphate, acid-catalysed, quinoline, Skraup reaction, Indole, Continuous
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C6GC03140D#!divAbstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information Continuous niobium phosphate catalysed Skraup reaction for quinoline synthesis from solketal J. Jin, S. Guidi, Z. Abada, Z. Amara, M. Selva, M. W. George and M. Poliakoff, Green Chem., 2017, 19, 2439 DOI: 10.1039/C6GC03140D Reproduced from Green Chemistry with permission from The Royal Society of Chemistry.

Files

GreenChem2017 19 2439.pdf (993 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





You might also like



Downloadable Citations

;