Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?
Steenblock, Charlotte; de Celis, Maria F. Rubin; Androutsellis-Theotokis, Andreas; Sue, Mariko; Delgadillo Silva, Luis F.; Eisenhofer, Graeme; Andoniadou, Cynthia L.; Bornstein, Stefan R.
Maria F. Rubin de Celis
Luis F. Delgadillo Silva
Cynthia L. Andoniadou
Stefan R. Bornstein
The adrenal gland is a highly plastic organ with the capacity to adapt the body homeostasis to different physiological needs. The existence of stem-like cells in the adrenal cortex has been revealed in many studies. Recently, we identified and characterized in mice a pool of glia-like multipotent Nestin-expressing progenitor cells, which contributes to the plasticity of the adrenal medulla. In addition, we found that these Nestin progenitors are actively involved in the stress response by giving rise to chromaffin cells. Interestingly, we also observed a Nestin-GFP-positive cell population located under the adrenal capsule and scattered through the cortex. In this article, we discuss the possibility of a common progenitor giving rise to subpopulations of cells both in the adrenal cortex and medulla, the isolation and characterization of this progenitor as well as its clinical potential in transplantation therapies and in pathophysiology.
|Journal Article Type||Article|
|Publication Date||Feb 5, 2017|
|Journal||Molecular and Cellular Endocrinology|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Steenblock, C., de Celis, M. F. R., Androutsellis-Theotokis, A., Sue, M., Delgadillo Silva, L. F., Eisenhofer, G., …Bornstein, S. R. (2017). Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?. Molecular and Cellular Endocrinology, 441, doi:10.1016/j.mce.2016.09.011|
|Keywords||adrenal medulla, adrenal cortex, stem cells, progenitors, stress, nestin|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf|