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Acetylcholinesterase activity measurement and clinical features of delirium

Jackson, T.A.; Moorey, H.C.; Sheehan, B.; Maclullich, A.M.J.; Gladman, J.R.F.; Lord, J.M.

Authors

T.A. Jackson t.jackson@bham.ac.uk

H.C. Moorey hannahclare.moorey@nhs.net

B. Sheehan bart.sheehan@ouh.nhs.uk

A.M.J. Maclullich a.maclullich@ed.ac.uk

J.R.F. Gladman john.gladman@nottingham.ac.uk

J.M. Lord j.m.lord@bham.ac.uk



Abstract

Aims: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum AChE activity and (1) clinical features of delirium and (2) outcomes, among older hospital patients with delirium.
Methods: Hospitalized patients with delirium were recruited and delirium motor subtype, severity and duration of delirium were measured. Serum AChE activity was measured using a colorimetric assay.
Results: The mean AChE activity for the whole sample was 2.46 μmol/μml/min (SD 1.75). Higher AChE activity was associated with increased likelihood of hypoactive delirium rather than the hyperactive or mixed subtype (OR 1.98, CI 1.10-3.59).
Conclusion: Higher AChE activity was associated with hypoactive delirium, but did not predict outcomes. Simple enhancement of cholinergic neurotransmission may not be sufficient to treat delirium

Journal Article Type Article
Publication Date Feb 1, 2017
Journal Dementia and Geriatric Cognitive Disorders
Print ISSN 1420-8008
Electronic ISSN 1421-9824
Publisher Karger Publishers
Peer Reviewed Peer Reviewed
Volume 43
Issue 1-2
APA6 Citation Jackson, T., Moorey, H., Sheehan, B., Maclullich, A., Gladman, J., & Lord, J. (2017). Acetylcholinesterase activity measurement and clinical features of delirium. Dementia and Geriatric Cognitive Disorders, 43(1-2), doi:10.1159/000452832
DOI https://doi.org/10.1159/000452832
Keywords Acetylcholinesterase activity, acetylcholine, delirium, cholinesterase inhibitors, aged, delirium motor subtype
Publisher URL https://www.karger.com/Article/Abstract/452832
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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