Rafael Penha
IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation
Penha, Rafael; Higgins, John; Mutamba, Shilla; Barrow, Paul; Mahida, Yashwant R.; Foster, Neil
Authors
John Higgins
Shilla Mutamba
Paul Barrow
Yashwant R. Mahida
Neil Foster
Abstract
We show that IL-36R is expressed by T (CD4+ and CD8+) and B (CD19+) lymphocytes in human blood and also by CD4+ T lymphocytes in the intestinal lamina propria. IL-36R protein was mostly stored in the cytoplasm of CD4 lymphocytes and B cells, during steady state conditions and the greatest expression of IL-36R mRNA was measured in CD4+ (T helper) lymphocytes. IL-36 ?, which functions via IL-36R induced rapid and significant (P < 0.05) proliferation of CD4+ lymphocytes, within 48 h. IL-36R expression was also maintained on the surface of circulating CD4+ lymphocytes which enter the intestinal lamina propria.
In conclusion our study is the first to show that (1) all human blood lymphocytes express IL-36R; (2) IL-36R expression is maintained by circulating CD4+ lymphocytes which enter the intestinal lamina propria and (3) IL-36R/IL-36 ? induces rapid CD4 lymphocyte proliferation. The possible significance of these results in the context of human disease is discussed.
Journal Article Type | Article |
---|---|
Acceptance Date | May 24, 2016 |
Online Publication Date | Jun 4, 2016 |
Publication Date | Sep 30, 2016 |
Deposit Date | Mar 27, 2017 |
Publicly Available Date | Mar 27, 2017 |
Journal | Cytokine |
Print ISSN | 1043-4666 |
Electronic ISSN | 1096-0023 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 85 |
DOI | https://doi.org/10.1016/j.cyto.2016.05.023 |
Keywords | IL-36; IL-36R; Human; Lymphocyte |
Public URL | https://nottingham-repository.worktribe.com/output/808595 |
Publisher URL | https://doi.org/10.1016/j.cyto.2016.05.023 |
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