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Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic

Ali, Waqas; Elsahn, Ahmad; Ting, Darren S. J.; Dua, Harminder S.; Mohammed, Imran

Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic Thumbnail


Waqas Ali

Ahmad Elsahn

Darren S. J. Ting

Professor of Ophthalmology and Visual Sciences

Imran Mohammed


One of the greatest challenges facing the medical community today is the ever-increasing trajectory of antimicrobial resistance (AMR), which is being compounded by the decrease in our antimicrobial armamentarium. From their initial discovery to the current day, antibiotics have seen an exponential increase in their usage, from medical to agricultural use. Benefits aside, this has led to an exponential increase in AMR, with the fear that over 10 million lives are predicted to be lost by 2050, according to the World Health Organisation (WHO). As such, medical researchers are turning their focus to discovering novel alternatives to antimicrobials, one being Host Defence Peptides (HDPs). These small cationic peptides have shown great efficacy in being used as an antimicrobial therapy for currently resistant microbial variants. With the sudden emergence of the SARS-CoV-2 variant and the subsequent global pandemic, the great versatility and potential use of HDPs as an alternative to conventional antibiotics in treating as well as preventing the spread of COVID-19 has been reviewed. Thus, to allow the reader to have a full understanding of the multifaceted therapeutic use of HDPs, this literature review shall cover the association between COVID-19 and AMR whilst discussing and evaluating the use of HDPs as an answer to antimicrobial resistance (AMR).

Journal Article Type Article
Acceptance Date Mar 24, 2022
Online Publication Date Apr 1, 2022
Publication Date Apr 1, 2022
Deposit Date Apr 7, 2022
Publicly Available Date Apr 7, 2022
Journal Antibiotics
Electronic ISSN 2079-6382
Publisher MDPI AG
Peer Reviewed Peer Reviewed
Volume 11
Issue 4
Article Number 475
Keywords Pharmacology (medical); Infectious Diseases; Microbiology (medical); General Pharmacology, Toxicology and Pharmaceutics; Biochemistry; Microbiology
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