Stefania Ferraro
Dysregulated anterior insula reactivity as robust functional biomarker for chronic pain—Meta-analytic evidence from neuroimaging studies
Ferraro, Stefania; Klugah-Brown, Benjamin; Tench, Christopher R.; Yao, Shuxia; Nigri, Anna; Demichelis, Greta; Pinardi, Chiara; Bruzzone, Maria Grazia; Becker, Benjamin
Authors
Benjamin Klugah-Brown
CHRISTOPHER TENCH CHRISTOPHER.TENCH@NOTTINGHAM.AC.UK
Research Fellow
Shuxia Yao
Anna Nigri
Greta Demichelis
Chiara Pinardi
Maria Grazia Bruzzone
Benjamin Becker
Contributors
CHRISTOPHER TENCH CHRISTOPHER.TENCH@NOTTINGHAM.AC.UK
Researcher
Abstract
Neurobiological pain models propose that chronic pain is accompanied by neurofunctional changes that mediate pain processing dysfunctions. In contrast, meta-analyses of neuroimaging studies in chronic pain conditions have not revealed convergent evidence for robust alterations during experimental pain induction. Against this background, the present neuroimaging meta-analysis combined three different meta-analytic approaches with stringent study selection criteria for case–control functional magnetic resonance imaging experiments during acute pain processing with a focus on chronic pain disorders. Convergent neurofunctional dysregulations in chronic pain patients were observed in the left anterior insula cortex. Seed-based resting-state functional connectivity based on a large publicly available dataset combined with a meta-analytic task-based approach identified the anterior insular region as a key node of an extended bilateral insula-fronto-cingular network, resembling the salience network. Moreover, the meta-analytic decoding showed that this region presents a high probability to be specifically activated during pain-related processes, although we cannot exclude an involvement in autonomic processes. Together, the present findings indicate that dysregulated left anterior insular activity represents a robust neurofunctional maladaptation and potential treatment target in chronic pain disorders.
Citation
Ferraro, S., Klugah-Brown, B., Tench, C. R., Yao, S., Nigri, A., Demichelis, G., …Becker, B. (2022). Dysregulated anterior insula reactivity as robust functional biomarker for chronic pain—Meta-analytic evidence from neuroimaging studies. Human Brain Mapping, 43(3), 998-1010. https://doi.org/10.1002/hbm.25702
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 19, 2021 |
Online Publication Date | Nov 3, 2021 |
Publication Date | Feb 15, 2022 |
Deposit Date | Mar 15, 2022 |
Publicly Available Date | Mar 18, 2022 |
Journal | Human Brain Mapping |
Print ISSN | 1065-9471 |
Electronic ISSN | 1097-0193 |
Peer Reviewed | Peer Reviewed |
Volume | 43 |
Issue | 3 |
Pages | 998-1010 |
DOI | https://doi.org/10.1002/hbm.25702 |
Public URL | https://nottingham-repository.worktribe.com/output/7605128 |
Publisher URL | https://onlinelibrary.wiley.com/doi/10.1002/hbm.25702 |
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Human Brain Mapping - 2021 - Ferraro - Dysregulated Anterior Insula Reactivity As Robust Functional Biomarker For Chronic
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
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