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Protective role of female gender in programmed accelerated renal aging in the rat

Pijacka, Wioletta; Clifford, Bethan; Tilburgs, Chantal; Joles, Jaap A.; Langley-Evans, Simon C.; McMullen, Sarah

Authors

Wioletta Pijacka

Bethan Clifford

Chantal Tilburgs

Jaap A. Joles

Sarah McMullen



Abstract

The aging kidney exhibits a progressive decline in glomerular filtration rate, accompanied by inflammatory and oxidative damage. We hypothesized that accelerated, age-related progression of renal injury is ovarian hormones-dependant. To address this we used an established model of developmentally programmed accelerated renal aging in the rat, superimposed by ovariectomy to assess interactions between ovarian hormones and the aging process. Under our experimental conditions, we found that kidney function worsens with age, that is GFR reduces over 18 month analyzed time-course and this was worsened by fetal exposure to maternal low-protein diet and absence of estrogen. Reduction in GFR was followed by increases in albuminuria, proteinuria, inflammatory markers, and tissue carbonyls, all suggesting inflammatory response and oxidative stress. This was associated with changes in AGTR2 expression which was greater at 18 months of age compared to earlier time points, but in MLP offspring only. Our studies show an influence of ovarian hormones on programmed accelerated renal aging and the AGTR2 across the lifespan. The main findings are that ovariectomy is a risk factor for increased aging-related renal injury and that this and oxidative damage might be related to changes in AGTR2 expression.

Journal Article Type Article
Publication Date Apr 22, 2015
Journal Physiological Reports
Electronic ISSN 2051-817X
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 3
Issue 4
Article Number e12342
APA6 Citation Pijacka, W., Clifford, B., Tilburgs, C., Joles, J. A., Langley-Evans, S. C., & McMullen, S. (2015). Protective role of female gender in programmed accelerated renal aging in the rat. Physiological Reports, 3(4), doi:10.14814/phy2.12342
DOI https://doi.org/10.14814/phy2.12342
Publisher URL http://physreports.physiology.org/content/3/4/e12342
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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