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Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

Smith-Jackson, Kate; Hentschke, Marta; Poli-de-Figueiredo, Carlos; Pinheiro da Costa, Bartira; Broughton Pipkin, Fiona; Czajka, Anna; Mistry, Hiten D.

Authors

Kate Smith-Jackson

Marta Hentschke

Carlos Poli-de-Figueiredo

Bartira Pinheiro da Costa

Fiona Broughton Pipkin

Anna Czajka

Hiten D. Mistry



Abstract

Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/ iNOS in normotensive control (n=24) and pre-eclamptic pregnancies (n=19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P

Citation

Smith-Jackson, K., Hentschke, M., Poli-de-Figueiredo, C., Pinheiro da Costa, B., Broughton Pipkin, F., Czajka, A., & Mistry, H. D. (2015). Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia. Placenta, 36(5), https://doi.org/10.1016/j.placenta.2015.02.001

Journal Article Type Article
Acceptance Date Feb 2, 2015
Publication Date Apr 1, 2015
Deposit Date Jul 21, 2017
Publicly Available Date Jul 21, 2017
Journal Placenta
Print ISSN 0143-4004
Electronic ISSN 1532-3102
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 36
Issue 5
DOI https://doi.org/10.1016/j.placenta.2015.02.001
Keywords Hypertension; Cavin; Caveolin; Pre-eclampsia; Placenta
Public URL http://eprints.nottingham.ac.uk/id/eprint/44328
Publisher URL http://www.sciencedirect.com/science/article/pii/S0143400415002684
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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