Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

Smith-Jackson, Kate; Hentschke, Marta; Poli-de-Figueiredo, Carlos; Pinheiro da Costa, Bartira; Broughton Pipkin, Fiona; Czajka, Anna; Mistry, Hiten D.

Abstract

Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/ iNOS in normotensive control (n=24) and pre-eclamptic pregnancies (n=19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P<0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P=0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.

Citation

Smith-Jackson, K., Hentschke, M., Poli-de-Figueiredo, C., Pinheiro da Costa, B., Broughton Pipkin, F., Czajka, A., & Mistry, H. D. (2015). Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia. Placenta, 36(5), https://doi.org/10.1016/j.placenta.2015.02.001

• Journal Article Type: Article
• Acceptance Date: Feb 2, 2015
• Publication Date: Apr 1, 2015
• Deposit Date: Jul 21, 2017
• Publicly Available Date: Jul 21, 2017
• Journal: Placenta
• Print ISSN: 0143-4004
• Electronic ISSN: 1532-3102
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 36
• Issue: 5
• DOI: https://doi.org/10.1016/j.placenta.2015.02.001
• Keywords: Hypertension; Cavin; Caveolin; Pre-eclampsia; Placenta
• Public URL: https://nottingham-repository.worktribe.com/output/746078
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0143400415002684
• Contract Date: Jul 21, 2017