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Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

Smith-Jackson, Kate; Hentschke, Marta; Poli-de-Figueiredo, Carlos; Pinheiro da Costa, Bartira; Broughton Pipkin, Fiona; Czajka, Anna; Mistry, Hiten D.

Authors

Kate Smith-Jackson

Marta Hentschke

Carlos Poli-de-Figueiredo

Bartira Pinheiro da Costa

Fiona Broughton Pipkin

Anna Czajka

Hiten D. Mistry hiten.mistry@nottingham.ac.uk



Abstract

Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/ iNOS in normotensive control (n=24) and pre-eclamptic pregnancies (n=19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P

Journal Article Type Article
Publication Date Apr 1, 2015
Journal Placenta
Print ISSN 0143-4004
Electronic ISSN 1532-3102
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 36
Issue 5
APA6 Citation Smith-Jackson, K., Hentschke, M., Poli-de-Figueiredo, C., Pinheiro da Costa, B., Broughton Pipkin, F., Czajka, A., & Mistry, H. D. (2015). Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia. Placenta, 36(5), https://doi.org/10.1016/j.placenta.2015.02.001
DOI https://doi.org/10.1016/j.placenta.2015.02.001
Keywords Hypertension; Cavin; Caveolin; Pre-eclampsia; Placenta
Publisher URL http://www.sciencedirect.com/science/article/pii/S0143400415002684
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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