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Impact of infection control interventions on rates of Staphylococcus aureus bacteraemia in National Health Service acute hospitals, East Midlands, UK, using interrupted time-series analysis

Newitt, S.; Myles, Puja R.; Birkin, J.A.; Maskell, V.; Slack, R.C.B.; Nguyen-Van-Tam, Jonathan; Szatkowski, Lisa

Authors

S. Newitt

Puja R. Myles puja.myles@nottingham.ac.uk

J.A. Birkin

V. Maskell

R.C.B. Slack



Abstract

Background: Reducing healthcare-associated infection (HCAI) is a UK national priority. Multiple national and regional interventions aimed at reduction have been implemented in National Health Service acute hospitals, but assessment of their effectiveness is methodologically challenging.

Aim: To assess the effectiveness of national and regional interventions undertaken between 2004 and 2008 on rates of meticillin-resistant Staphylococcus aureus (MRSA) and meticillin-sensitive Staphylococcus aureus (MSSA) bacteraemia within acute hospitals in the East Midlands, using interrupted time-series analysis.

Methods: We used segmented regression to compare rates of MRSA and MSSA bacteraemia in the pre-intervention, implementation, and post-intervention phases for combined intervention packages in eight acute hospitals.

Findings: Most of the change in MSSA and MRSA rates occurred during the implementation phase. During this phase, there were significant downward trends in MRSA rates for seven of eight acute hospital groups; in four, this was a steeper quarter-on-quarter decline compared with the pre-intervention phase, and, in one, an upward trend in the pre-intervention phase was reversed. Regarding MSSA, there was a significant positive effect in four hospital groups: one upward trend during the pre-intervention phase was reversed, two upward trends plateaued, and in one hospital group an indeterminate trend decreased significantly. However, there were significant increasing trends in quarterly MSSA rates in four hospital groups during the implementation or post-intervention periods. Conclusion The impact of interventions varied by hospital group but the overall results suggest that national and regional campaigns had a beneficial impact on MRSA and MSSA bacteraemia within the East Midlands.

Journal Article Type Article
Journal Journal of Hospital Infection
Print ISSN 0195-6701
Electronic ISSN 1532-2939
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 90
Issue 1
APA6 Citation Newitt, S., Myles, P. R., Birkin, J., Maskell, V., Slack, R., Nguyen-Van-Tam, J., & Szatkowski, L. (in press). Impact of infection control interventions on rates of Staphylococcus aureus bacteraemia in National Health Service acute hospitals, East Midlands, UK, using interrupted time-series analysis. Journal of Hospital Infection, 90(1), https://doi.org/10.1016/j.jhin.2014.12.016
DOI https://doi.org/10.1016/j.jhin.2014.12.016
Keywords Healthcare-associated infection, MRSA, MSSA, Time-series analysis
Publisher URL http://www.sciencedirect.com/science/article/pii/S0195670115000341
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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