Effect of ethnicity on care pathway and outcomes in patients hospitalized with influenza A(H1N1)pdm09 in the UK

Nyland, G.A.; McKenzie, B.C.; Myles, Puja R.; Semple, M.G.; Lim, W.S.; Openshaw, Peter J.M.; Read, R.C.; Taylor, B.L.; Brett, S.J.; Mcmenamin, J.; Enstone, J.E.; Bannister, B.; Nicholson, K.G.; Nguyen-Van-Tam, Jonathan

Abstract

Data were extracted from the case records of UK patients admitted with laboratory-confirmed influenza A(H1N1)pdm09. White and non-White patients were characterized by age, sex, socioeconomic status, pandemic wave and indicators of pre-morbid health status. Logistic regression examined differences by ethnicity in patient characteristics, care pathway and clinical outcomes; multivariable models controlled for potential confounders. Whites (n = 630) and non-Whites (n = 510) differed by age, socioeconomic status, pandemic wave of admission, pregnancy, recorded obesity, previous and current smoking, and presence of chronic obstructive pulmonary disease. After adjustment for a priori confounders non-Whites were less likely to have received pre-admission antibiotics [adjusted odds ratio (aOR) 0·43, 95% confidence interval (CI) 0·28–0·68, P < 0·001) but more likely to receive antiviral drugs as in-patients (aOR 1·53, 95% CI 1·08–2·18, P = 0·018). However, there were no significant differences by ethnicity in delayed admission, severity at presentation for admission, or likelihood of severe outcome.

Citation

Nyland, G., McKenzie, B., Myles, P. R., Semple, M., Lim, W., Openshaw, P. J., Read, R., Taylor, B., Brett, S., Mcmenamin, J., Enstone, J., Bannister, B., Nicholson, K., & Nguyen-Van-Tam, J. (in press). Effect of ethnicity on care pathway and outcomes in patients hospitalized with influenza A(H1N1)pdm09 in the UK. Epidemiology and Infection, 143(6), https://doi.org/10.1017/S0950268814001873

• Journal Article Type: Article
• Acceptance Date: Jul 14, 2014
• Online Publication Date: Aug 1, 2014
• Deposit Date: Oct 20, 2016
• Publicly Available Date: Oct 20, 2016
• Journal: Epidemiology & Infection
• Print ISSN: 0950-2688
• Electronic ISSN: 1469-4409
• Publisher: Cambridge University Press
• Peer Reviewed: Peer Reviewed
• Volume: 143
• Issue: 6
• DOI: https://doi.org/10.1017/S0950268814001873
• Keywords: Epidemiology, influenza, influenza A, pandemic
• Public URL: https://nottingham-repository.worktribe.com/output/731457
• Publisher URL: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/effect-of-ethnicity-on-care-pathway-and-outcomes-in-patients-hospitalized-with-influenza-ah1n1pdm09-in-the-uk/5990C205BD084C25FD3D8AA3FD820F69
• Contract Date: Oct 20, 2016