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Functional quantitative susceptibility mapping (fQSM)

Balla, Dávid Z.; Sánchez-Panchuelo, Rosa-Maria; Wharton, Samuel J.; Hagberg, Gisela E.; Scheffler, Klaus; Francis, Susan T.; Bowtell, Richard

Authors

Dávid Z. Balla

Rosa-Maria Sánchez-Panchuelo

Samuel J. Wharton

Gisela E. Hagberg

Klaus Scheffler

Susan T. Francis

Richard Bowtell richard.bowtell@nottingham.ac.uk



Abstract

Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is a powerful technique, typically based on the statistical analysis of the magnitude component of the complex time-series. Here, we additionally interrogated the phase data of the fMRI time-series and used quantitative susceptibility mapping (QSM) in order to investigate the potential of functional QSM (fQSM) relative to standard magnitude BOLD fMRI. High spatial resolution data (1 mm isotropic) were acquired every 3 seconds using zoomed multi-slice gradient-echo EPI collected at 7 T in single orientation (SO) and multiple orientation (MO) experiments, the latter involving 4 repetitions with the subject's head rotated relative to B0. Statistical parametric maps (SPM) were reconstructed for magnitude, phase and QSM time-series and each was subjected to detailed analysis. Several fQSM pipelines were evaluated and compared based on the relative number of voxels that were coincidentally found to be significant in QSM and magnitude SPMs (common voxels). We found that sensitivity and spatial reliability of fQSM relative to the magnitude data depended strongly on the arbitrary significance threshold defining “activated” voxels in SPMs, and on the efficiency of spatio-temporal filtering of the phase time-series. Sensitivity and spatial reliability depended slightly on whether MO or SO fQSM was performed and on the QSM calculation approach used for SO data. Our results present the potential of fQSM as a quantitative method of mapping BOLD changes. We also critically discuss the technical challenges and issues linked to this intriguing new technique.

Journal Article Type Article
Publication Date Oct 15, 2014
Journal NeuroImage
Print ISSN 1053-8119
Electronic ISSN 1095-9572
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 100
Pages 112-124
APA6 Citation Balla, D. Z., Sánchez-Panchuelo, R., Wharton, S. J., Hagberg, G. E., Scheffler, K., Francis, S. T., & Bowtell, R. (2014). Functional quantitative susceptibility mapping (fQSM). NeuroImage, 100, 112-124. https://doi.org/10.1016/j.neuroimage.2014.06.011
DOI https://doi.org/10.1016/j.neuroimage.2014.06.011
Keywords fMRI; Functional QSM; MR phase imaging; Susceptibility mapping; Quantitative BOLD; Specific brain activation
Publisher URL http://www.sciencedirect.com/science/article/pii/S1053811914004881
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This article is maintained by: Elsevier; Article Title: Functional quantitative susceptibility mapping (fQSM); Journal Title: NeuroImage; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.neuroimage.2014.06.011; Content Type: article; Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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