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Characterisation of the horse transcriptome from immunologically active tissues

Moreton, Joanna; Malla, Sunir; Aboobaker, Aziz; Tarlinton, Rachael E.; Emes, Richard D.

Authors

Joanna Moreton

Sunir Malla

Aziz Aboobaker

Rachael E. Tarlinton

RICHARD EMES richard.emes@nottingham.ac.uk
Professor of Bioinformatics



Abstract

The immune system of the horse has not been well studied, despite the fact that the horse displays several features such as sensitivity to bacterial lipopolysaccharide that make them in many ways a more suitable model of some human disorders than the current rodent models. The difficulty of working with large animal models has however limited characterisation of gene expression in the horse immune system with current annotations for the equine genome restricted to predictions from other mammals and the few described horse proteins. This paper outlines sequencing of 184 million transcriptome short reads from immunologically active tissues of three horses including the genome reference “Twilight”. In a comparison with the Ensembl horse genome annotation, we found 8,763 potentially novel isoforms.

Journal Article Type Article
Publication Date May 6, 2014
Journal PeerJ
Electronic ISSN 2167-8359
Publisher PeerJ
Peer Reviewed Peer Reviewed
Volume 2
Article Number e382
APA6 Citation Moreton, J., Malla, S., Aboobaker, A., Tarlinton, R. E., & Emes, R. D. (2014). Characterisation of the horse transcriptome from immunologically active tissues. PeerJ, 2, https://doi.org/10.7717/peerj.382
DOI https://doi.org/10.7717/peerj.382
Publisher URL https://peerj.com/articles/382/
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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