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Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses

Sun, H.; Sun, Y.; Pu, J.; Zhang, Y.; Zhu, Q.; Li, J.; Gu, J.; Chang, K.-C.; Liu, J.

Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses Thumbnail


Authors

H. Sun

Y. Sun

J. Pu

Y. Zhang

Q. Zhu

J. Li

J. Gu

KIN-CHOW CHANG KIN-CHOW.CHANG@NOTTINGHAM.AC.UK
Professor of Veterinary Molecular Medicine

J. Liu



Abstract

Highly pathogenic avian influenza H5N1 virus clades 2.3.4, 2.3.2, and 7 are the dominant cocirculating H5N1 viruses in poultry in China. However, humans appear to be clinically susceptible mostly to the 2.3.4 virus clade. Here, we demonstrated that A549 cells and human macrophages infected with clade 2.3.4 viruses produced significantly more viruses than those infected with the other two clades. Likewise, clade 2.3.4-infected macrophages caused the most severe cellular damage and strongest proinflammatory response.

Citation

Sun, H., Sun, Y., Pu, J., Zhang, Y., Zhu, Q., Li, J., …Liu, J. (2014). Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses. Journal of Virology, 88(1), https://doi.org/10.1128/JVI.02510-13

Journal Article Type Article
Acceptance Date Oct 5, 2013
Online Publication Date Oct 16, 2013
Publication Date Jan 3, 2014
Deposit Date Jun 30, 2017
Publicly Available Date Jun 30, 2017
Journal Journal of Virology
Print ISSN 0022-538X
Electronic ISSN 0022-538X
Publisher American Society for Microbiology
Peer Reviewed Peer Reviewed
Volume 88
Issue 1
DOI https://doi.org/10.1128/JVI.02510-13
Public URL https://nottingham-repository.worktribe.com/output/722353
Publisher URL http://jvi.asm.org/content/88/1/725

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