Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses

Sun, H.; Sun, Y.; Pu, J.; Zhang, Y.; Zhu, Q.; Li, J.; Gu, J.; Chang, K.-C.; Liu, J.

Abstract

Highly pathogenic avian influenza H5N1 virus clades 2.3.4, 2.3.2, and 7 are the dominant cocirculating H5N1 viruses in poultry in China. However, humans appear to be clinically susceptible mostly to the 2.3.4 virus clade. Here, we demonstrated that A549 cells and human macrophages infected with clade 2.3.4 viruses produced significantly more viruses than those infected with the other two clades. Likewise, clade 2.3.4-infected macrophages caused the most severe cellular damage and strongest proinflammatory response.

Citation

Sun, H., Sun, Y., Pu, J., Zhang, Y., Zhu, Q., Li, J., Gu, J., Chang, K.-C., & Liu, J. (2014). Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses. Journal of Virology, 88(1), https://doi.org/10.1128/JVI.02510-13

• Journal Article Type: Article
• Acceptance Date: Oct 5, 2013
• Online Publication Date: Oct 16, 2013
• Publication Date: Jan 3, 2014
• Deposit Date: Jun 30, 2017
• Publicly Available Date: Jun 30, 2017
• Journal: Journal of Virology
• Print ISSN: 0022-538X
• Electronic ISSN: 1098-5514
• Publisher: American Society for Microbiology
• Peer Reviewed: Peer Reviewed
• Volume: 88
• Issue: 1
• DOI: https://doi.org/10.1128/JVI.02510-13
• Public URL: https://nottingham-repository.worktribe.com/output/722353
• Publisher URL: http://jvi.asm.org/content/88/1/725
• Contract Date: Jun 30, 2017