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Investigating the microrheology of the vitreous humor using an optically trapped local probe

Watts, Fiona; Tan, Lay Ean; Wilson, Clive G.; Girkin, John M.; Tassieri, Manlio; Wright, Amanda J.

Authors

Fiona Watts

Lay Ean Tan

Clive G. Wilson

John M. Girkin

Manlio Tassieri

Amanda J. Wright



Abstract

We demonstrate that an optically trapped silica bead can be used as a local probe to measure the micro-rheology of the vitreous humor. The Brownian motion of the bead was observed using a fast camera and the micro-rheology determined by analysis of the time-dependent mean-square displacement of the bead. We observed regions of the vitreous that showed different degrees of viscoelasticity, along with the homogeneous and inhomogeneous nature of different regions. The motivation behind this study is to understand the vitreous structure, in particular changes due to aging, allowing more confident prediction of pharmaceutical drug behavior and delivery within the vitreous humor.

Citation

Watts, F., Tan, L. E., Wilson, C. G., Girkin, J. M., Tassieri, M., & Wright, A. J. (2013). Investigating the microrheology of the vitreous humor using an optically trapped local probe. Journal of Optics, 16(1), https://doi.org/10.1088/2040-8978/16/1/015301

Journal Article Type Article
Acceptance Date Nov 18, 2013
Publication Date Dec 11, 2013
Deposit Date Aug 10, 2016
Publicly Available Date Aug 10, 2016
Journal Journal of Optics
Print ISSN 2040-8978
Electronic ISSN 2040-8986
Publisher IOP Publishing
Peer Reviewed Peer Reviewed
Volume 16
Issue 1
DOI https://doi.org/10.1088/2040-8978/16/1/015301
Keywords optical trapping, micro-rheology, vitreous humor
Public URL http://eprints.nottingham.ac.uk/id/eprint/35795
Publisher URL http://iopscience.iop.org/article/10.1088/2040-8978/16/1/015301
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Publisher Licence URL
http://creativecommons.org/licenses/by/3.0/





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