Skip to main content

Research Repository

Advanced Search

Effects of image reconstruction on fiber orientation mapping from multichannel diffusion MRI: reducing the noise floor using SENSE

Sotiropoulos, S.N.; Moeller, S.; Jbabdi, S.; Xu, J.; Andersson, J.L.; Auerbach, E.J.; Yacoub, E.; Feinberg, D.; Setsompop, K.; Wald, L.L.; Behrens, T.E.J.; Ugurbil, K.; Lenglet, C.

Authors

S.N. Sotiropoulos

S. Moeller

S. Jbabdi

J. Xu

J.L. Andersson

E.J. Auerbach

E. Yacoub

D. Feinberg

K. Setsompop

L.L. Wald

T.E.J. Behrens

K. Ugurbil

C. Lenglet



Abstract

Purpose: To examine the effects of the reconstruction algorithm of magnitude images from multi-channel diffusion MRI on fibre orientation estimation.
Theory and Methods: It is well established that the method used to combine signals from different coil elements in multi-channel MRI can have an impact on the properties of the reconstructed magnitude image. Utilising a root-sum-of-squares (RSoS) approach results in a magnitude signal that follows an effective non-central-distribution. As a result, the noise floor, the minimum measurable in the absence of any true signal, is elevated. This is particularly relevant for diffusion-weighted MRI, where the signal attenuation is of interest.
Results: In this study, we illustrate problems that such image reconstruction characteristics may cause in the estimation of fibre orientations, both for model-based and model-free approaches, when modern 32-channel coils are employed. We further propose an alternative image reconstruction method that is based on sensitivity encoding (SENSE) and preserves the Rician nature of the single-channel, magnitude MR signal. We show that for the same k-space data, RSoS can cause excessive overfitting and reduced precision in orientation estimation compared to the SENSE-based approach.
Conclusion: These results highlight the importance of choosing the appropriate image reconstruction method for tractography studies that use multi-channel receiver coils for diffusion MRI acquisition.

Citation

Sotiropoulos, S., Moeller, S., Jbabdi, S., Xu, J., Andersson, J., Auerbach, E., …Lenglet, C. (2013). Effects of image reconstruction on fiber orientation mapping from multichannel diffusion MRI: reducing the noise floor using SENSE. Magnetic Resonance in Medicine, 70(6), https://doi.org/10.1002/mrm.24623

Journal Article Type Article
Acceptance Date Dec 9, 2012
Online Publication Date Feb 7, 2013
Publication Date Nov 18, 2013
Deposit Date Jul 11, 2018
Publicly Available Date Jul 11, 2018
Journal Magnetic Resonance in Medicine
Print ISSN 0740-3194
Electronic ISSN 1522-2594
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 70
Issue 6
DOI https://doi.org/10.1002/mrm.24623
Keywords Sum of Squares; SENSE; Rician; Non-central-X; Magnitude Image; Tractography
Public URL http://eprints.nottingham.ac.uk/id/eprint/52875
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.24623
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is the peer reviewed version of the following article, which has been published in final form at https://onlinelibrary.w.../abs/10.1002/mrm.24623. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Files

nihms428785.pdf (2.8 Mb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





Downloadable Citations