Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy.

Ghita, Adrian; Pascut, Flavius C.; Sottile, Virginie; Notingher, Ioan

Abstract

Raman microscopy was used as a label-free method to study the mineralisation of bone nodules formed by mesenchymal stem cells cultured in osteogenic medium in vitro. Monitoring individual bone nodules over 28 days revealed temporal and spatial changes in the crystalline phase of the hydroxyapatite components of the nodules.

Citation

Ghita, A., Pascut, F. C., Sottile, V., & Notingher, I. (2013). Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy. Analyst, 139(1), https://doi.org/10.1039/C3AN01716H

• Journal Article Type: Article
• Acceptance Date: Oct 15, 2013
• Publication Date: Oct 16, 2013
• Deposit Date: Feb 21, 2018
• Journal: Analyst
• Print ISSN: 0003-2654
• Electronic ISSN: 1364-5528
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 139
• Issue: 1
• DOI: https://doi.org/10.1039/C3AN01716H
• Public URL: https://nottingham-repository.worktribe.com/output/718707
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2014/AN/C3AN01716H#!divAbstract
• Contract Date: Feb 21, 2018