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Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy.

Ghita, Adrian; Pascut, Flavius C.; Sottile, Virginie; Notingher, Ioan

Authors

Adrian Ghita

Flavius C. Pascut

Virginie Sottile



Abstract

Raman microscopy was used as a label-free method to study the mineralisation of bone nodules formed by mesenchymal stem cells cultured in osteogenic medium in vitro. Monitoring individual bone nodules over 28 days revealed temporal and spatial changes in the crystalline phase of the hydroxyapatite components of the nodules.

Journal Article Type Article
Publication Date Oct 16, 2013
Journal Analyst
Print ISSN 0003-2654
Electronic ISSN 1364-5528
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 139
Issue 1
APA6 Citation Ghita, A., Pascut, F. C., Sottile, V., & Notingher, I. (2013). Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy. Analyst, 139(1), doi:10.1039/C3AN01716H
DOI https://doi.org/10.1039/C3AN01716H
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2014/AN/C3AN01716H#!divAbstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
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