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Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle

Lehmann, Susann; Bass, Joseph J.; Szewczyk, N.J.

Authors

Susann Lehmann

Joseph J. Bass

N.J. Szewczyk

Abstract

Kinases are important signalling molecules for modulating cellular processes and major targets of drug discovery programs. However, functional information for roughly half the human kinome is lacking. We conducted three kinome wide, >90%, RNAi screens and epistasis testing of some identified kinases against known intramuscular signalling systems to increase the functional annotation of the C. elegans kinome and expand our understanding of kinome influence upon muscle protein degradation.

Journal Article Type Article
Publication Date Sep 23, 2013
Journal Cell Communication & Signaling
Electronic ISSN 1478-811X
Publisher Humana Press
Peer Reviewed Peer Reviewed
Volume 11
Issue 71
Institution Citation Lehmann, S., Bass, J. J., & Szewczyk, N. (2013). Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle. Cell Communication and Signaling, 11(71), doi:10.1186/1478-811X-11-71
DOI https://doi.org/10.1186/1478-811X-11-71
Publisher URL http://www.biosignaling.com/content/11/1/71
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0




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