Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle
Lehmann, Susann; Bass, Joseph J.; Szewczyk, N.J.
Joseph J. Bass
Kinases are important signalling molecules for modulating cellular processes and major targets of drug discovery programs. However, functional information for roughly half the human kinome is lacking. We conducted three kinome wide, >90%, RNAi screens and epistasis testing of some identified kinases against known intramuscular signalling systems to increase the functional annotation of the C. elegans kinome and expand our understanding of kinome influence upon muscle protein degradation.
|Journal Article Type||Article|
|Publication Date||Sep 23, 2013|
|Journal||Cell Communication & Signaling|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Lehmann, S., Bass, J. J., & Szewczyk, N. (2013). Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle. Cell Communication and Signaling, 11(71), doi:10.1186/1478-811X-11-71|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0|
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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