A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms

Kadam, Rameshwar U.; Bergmann, Myriam; Hurley, Matthew; Garg, Divita; Cacciarini, Martina; Swiderska, Magdalena A.; Nativi, Cristina; Sattler, Michael; Smyth, Alan R.; Williams, Paul; C�mara, Miguel; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis

Abstract

Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction.

Citation

Kadam, R. U., Bergmann, M., Hurley, M., Garg, D., Cacciarini, M., Swiderska, M. A., …Reymond, J. (2011). A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms. Angewandte Chemie International Edition, 50(45), https://doi.org/10.1002/anie.201104342

• Journal Article Type: Article
• Publication Date: Nov 4, 2011
• Deposit Date: Apr 4, 2014
• Publicly Available Date: Apr 4, 2014
• Journal: Angewandte Chemie International Edition
• Print ISSN: 1433-7851
• Electronic ISSN: 1521-3773
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 50
• Issue: 45
• DOI: https://doi.org/10.1002/anie.201104342
• Public URL: https://nottingham-repository.worktribe.com/output/708770
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/anie.201104342/abstract