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A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms

Kadam, Rameshwar U.; Bergmann, Myriam; Hurley, Matthew; Garg, Divita; Cacciarini, Martina; Swiderska, Magdalena A.; Nativi, Cristina; Sattler, Michael; Smyth, Alan R.; Williams, Paul; Cámara, Miguel; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis

Authors

Rameshwar U. Kadam

Myriam Bergmann

Matthew Hurley

Divita Garg

Martina Cacciarini

Magdalena A. Swiderska

Cristina Nativi

Michael Sattler

Alan R. Smyth alan.smyth@nottingham.ac.uk

Paul Williams

Miguel Cámara

Achim Stocker

Tamis Darbre

Jean-Louis Reymond



Abstract

Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the linker between the peptide dendrimer and the galactose can provide additional contacts to the lectin and also has an effect on the interaction.

Journal Article Type Article
Publication Date Nov 4, 2011
Journal Angewandte Chemie International Edition
Print ISSN 1433-7851
Electronic ISSN 1433-7851
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 50
Issue 45
Institution Citation Kadam, R. U., Bergmann, M., Hurley, M., Garg, D., Cacciarini, M., Swiderska, M. A., …Reymond, J. (2011). A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms. Angewandte Chemie International Edition, 50(45), doi:10.1002/anie.201104342
DOI https://doi.org/10.1002/anie.201104342
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/anie.201104342/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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