Pharmacogenomic testing to support prescribing in primary care: A structured review of implementation models

Hayward, Judith; McDermott, John; Qureshi, Nadeem; Newman, William

Abstract

The application of pharmacogenomics could meaningfully contribute toward medicines optimization within primary care. This review identified 13 studies describing eight implementation models utilizing a multi-gene pharmacogenomic panel within a primary care or community setting. These were small feasibility studies (n <200). They demonstrated importance and feasibility of pre-test counseling, the role of the pharmacist, data integration into the electronic medical record and point-of-care clinical decision support systems (CDSS). Findings were considered alongside existing primary care prescribing practices and implementation frameworks to demonstrate how issues may be addressed by existing nationalized healthcare and primary care infrastructure. Development of point-of-care CDSS should be prioritized; establishing clinical leadership, education programs, defining practitioner roles and responsibilities and addressing commissioning issues will also be crucial.

• Journal Article Type: Review
• Acceptance Date: Jun 24, 2021
• Online Publication Date: Sep 1, 2021
• Publication Date: Aug 1, 2021
• Deposit Date: Sep 13, 2021
• Publicly Available Date: Sep 14, 2021
• Journal: Pharmacogenomics
• Print ISSN: 1462-2416
• Electronic ISSN: 1744-8042
• Publisher: Future Medicine Ltd
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Issue: 12
• Pages: 761-777
• DOI: https://doi.org/10.2217/pgs-2021-0032
• Keywords: Pharmacology, Genetics, Molecular Medicine, community, implementation, medicines optimisation, pharmacogenomics, prescribing, primary care
• Public URL: https://nottingham-repository.worktribe.com/output/6237814
• Publisher URL: https://www.futuremedicine.com/doi/10.2217/pgs-2021-0032#d1804513e1