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Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Abani, Obbina; Abbas, Ali; Abbas, Fatima; Abbas, Mustafa; Abbasi, Sadia; Abbass, Hakam; Abbott, Alfie; Abdallah, Nabeel; Abdelaziz, Ashraf; Abdelfattah, Mohamed; Abdelqader, Bushra; Abdo, David; Abdul, Basir; Abdul Rasheed, Althaf; Abdulakeem, Ajibode; Abdul-Kadir, Rezan; Abdulle, Amina; Abdulmumeen, Abdulfatahi; Abdul-Raheem, Rasheed; Abdulshukkoor, Niyaz; Abdusamad, Kula; Abed El Khaleq, Yazeed; Abedalla, Mai; Abeer Ul Amna, Abeer Ul Amna; Abernethy, Katrina; Aboaba, Adebanke; Abo-Leyah, Hani; Abou-Haggar, Ahmed; Abouibrahim, Mahmoud; Abraham, Miriam; Abraham, Tizzy; Abraheem, Abraheem; Abrams, Judith; Abu, Hyacinth-John; Abu-Arafeh, Ahmed; Abubacker, Syed M; Abung, Akata; Aceampong, Yaa; Achara, Amaka; Acharya, Devikumar; Acheampong, Sarah; Acheson, Janet; Acosta, Andres; Acton, Catherine; Adabie-Ankrah, Jacqueline; Adair, Sara; Adam, Fiona; Adam, Matthew; Adamali, Huzaifa; Adams, Carol; Adams, Charlotte; Adams, Kate; Adams, Lisa; Adams, Richard; Adams, Tim; Adcock, Kirsty; Addai, J...

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial Thumbnail


Authors

Obbina Abani

Ali Abbas

Fatima Abbas

Mustafa Abbas

Sadia Abbasi

Hakam Abbass

Alfie Abbott

Nabeel Abdallah

Ashraf Abdelaziz

Mohamed Abdelfattah

Bushra Abdelqader

David Abdo

Basir Abdul

Althaf Abdul Rasheed

Ajibode Abdulakeem

Rezan Abdul-Kadir

Amina Abdulle

Abdulfatahi Abdulmumeen

Rasheed Abdul-Raheem

Niyaz Abdulshukkoor

Kula Abdusamad

Yazeed Abed El Khaleq

Mai Abedalla

Abeer Ul Amna Abeer Ul Amna

Katrina Abernethy

Adebanke Aboaba

Hani Abo-Leyah

Ahmed Abou-Haggar

Mahmoud Abouibrahim

Miriam Abraham

Tizzy Abraham

Abraheem Abraheem

Judith Abrams

Hyacinth-John Abu

Ahmed Abu-Arafeh

Syed M Abubacker

Akata Abung

Yaa Aceampong

Amaka Achara

Devikumar Acharya

Sarah Acheampong

Janet Acheson

Andres Acosta

Catherine Acton

Jacqueline Adabie-Ankrah

Sara Adair

Fiona Adam

Matthew Adam

Huzaifa Adamali

Carol Adams

Charlotte Adams

Kate Adams

Lisa Adams

Richard Adams

Tim Adams

Kirsty Adcock

Jemaimah Addai

Ade Adebiyi

Ken Adegoke

Vicki Adell

Debo Ademokun

Sherna Adenwalla

Oluwasegun A Adesemoye

Emmanuel O Adewunmi

Joyce Adeyemi

Rina Adhikary

Gabrielle Adkins

Adnan Adnan

John Aeron-Thomas

Debbie Affleck

Dominic Affron

Carmel Afnan

Muhammad Afridi

Zainab A Aftab

Meenakshi Agarwal

Rachel Agbeko

Chris Agbo

Penny Agent

Sunil Aggarwal

Arameh Aghababaie

Shafana Ahamed Sadiq

Mohamed H Ahammed Nazeer

Humayun Ahmad

Mohammad Ahmad

Syed Ahmad

Asim Ahmed

Bilal Ahmed

Forizuddin Ahmed

Hamze Ahmed

Iram Ahmed

Irshad Ahmed

Khaled Ahmed

Liban Ahmed

Mahin Ahmed

Maria C Ahmed

Muhammad S Ahmed

Naseer Ahmed

Nausheen Ahmed

Osama Ahmed

Rajia A Ahmed

Rizwan Ahmed

Saif Ahmed

Sammiya Ahmed

Sara Ahmed

Sophia Ahmed

Syed Ahmed

Syed Haris Ahmed

Roa Ahmed Ali

Sana Ahmed

Sana Ahmer

Dhiraj Ail

Mark Ainsworth

Giulia Airoldi

Myriam Aissa

Lindianne Aitken

Bini Ajay

Francis Ajeneye

Abdulakeem Ajibode

Ayesha Ajmi

Tahir Akbar

Naim Akhtar

Nasim Akhtar

Nauman Akhtar

Suha Akili

Oludoyinsola Akindolie

Yinka Akinfenwa

Olugbenga Akinkugbe

Ibrahim Akinpelu

Olajide Akinwumiju

Olugbenro Aktinade

Ahmad Al Aaraj

Asma Al Balushi

Majd Al Dakhola

Aladdin Al Swaifi

Eslam Al-Abadi

Narendra Aladangady

Ayaz Alam

Sajid Alam

Abbas Al-Asadi

Karina Al-Asadi

Kyriaki Alatzoglou

Manaf Al-Bayati

Paul Albert

Lorraine Albon

Gemma Alcorn

Stephen Alcorn

Aggie Aldana

David Alderdice

Rayan Aldouri

Jonathan Aldridge

Nicolas Aldridge

Ana Alegria

Alison Alexander

John Alexander

Peter D G Alexander

Charlotte Alford

Julyan Al-Fori

Laith Alghazawi

Bahij Al-Hakim

Shams Al-Hity

Ali Ali

Asad Ali

Fawzia R Ali

Hoodo Ali

Jawad Ali

Mariam Ali

Mohammad Ali

Nayab Ali

Oudai Ali

Sabira Ali

Sakina Ali

Syed Ali

Abid Alina

Fine Aliyuda

Katrin Alizadeh

Maithem Al-Jibury

Saba Al-Juboori

Majid Al-Khalil

Moutaz Alkhusheh

Allameddine Allameddine

Fiona Allan

Rachel Allan

Alison Allanson

Robert Allcock

Beverley Allen

Eireann Allen

Jess Allen

Kerry Allen

Laura Allen

Louise Allen

Poppy Allen

Rebecca Allen

Sam Allen

Sharon Allen

Simon Allen

Kathryn Allison

Bethan Allman

Lynne Allsop

Hassan Al-Moasseb

Magda Al-Obaidi

Lina Alomari

Akram Al-Rabahi

Bahar Al-Ramadhani

Zayneb Al-Saadi

Inji Alshaer

Rustam Al-Shahi Salman

Warkaq Al-Shamkhani

Bashar Al-Sheklly

Sara Altaf

Mary Alvarez

Balaal Alyas

Maysaa Alzetani

Susan Amamou

Noor Amar

Sakkarai Ambalavanan

Sarah-Jayne Ambler

Robert Ambrogetti

Chris Ambrose

Amir Ameen

Kenneth Amenyah

Maria R Amezaga

Allison Amin

Amina Amin

Kanish Amin

Syed Amin

Tara Amin

Amjad Amjad

Neelma Amjad

Mariam Ammoun

Victoria Amosun

Khaled Amsha

Pugh Amy

Atul Anand

Rekha Anand

Samantha Anandappa

Julie Anderson

Kevin Anderson

Laura Anderson

Michelle Anderson

Nicola Anderson

Rachel Anderson

Rory Anderson

Wendy Anderson

Prematie Andreou

Angela Andrews

Antonette Andrews

Jill Andrews

Susan Andrews

Gregory Andrikopoulos

Kanayochukwu Aneke

Andrew Ang

Wan Wei Ang

Tammy Angel

Aramburo Angela

Paola Angelini

Lazarus Anguvaa

Oleg Anichtchik

Millicent Anim-Somuah

Krishnan Aniruddhan

Jessica Annett

Patrick J Anstey

Rebekah Anstey

Alpha Anthony

Aaron Anthony-Pillai

Philip Antill

Zhelyazkova Antonina

Varghese Anu

Muhammad Anwar

George Apostolides

Aristeidis Apostolopoulos

Sarah Appleby

Diane Appleyard

Maia Far Aquino

Bianca Araba

Samuel Aransiola

Mariana Araujo

Emily Arbon

Ann Archer

Denise Archer

Simon Archer

Christian Ardley

Ana-Maria Arias

Ryoki Arimoto

Charlotte Arkley

Charlotte Armah

Ilianna Armata

Adam Armitage

Ceri Armstrong

Maureen Armstrong

Sonia Armstrong

Sylvia Armstrong-Fisher

Philippa Armtrong

Heike Arndt

Clare Arnison-Newgass

David Arnold

Rachael Arnold

Sarah Arnott

Dhawal Arora

Kavan Arora

Pardeep Arora

Rishi Arora

Andrea Arroyo

Arslam Arter

Ayush Arya

Rita Arya

Denisa Asandei

Adeeba Asghar

Catherine Ashbrook-Raby

Glen Ashby

Helen Ashby

Jan Ashcroft

John Ashcroft

Samuel Ashcroft

Deborah Asher

Ayesha Ashfaq

Ben Ashford

Suhail Ashgar

Abdul Ashish

Sally Ashman-Flavell

Sundar Ashok

Abd-El-Aziz Ashour

Muhammad Z Ashraf

Saima Ashraf

Mohammad B Ashraq

Deborah Ashton

Susan Ashton

Andrew Ashworth

Rebecca Ashworth

Arshia Aslam

Harshini Asogan

Abigail Asquith

Atif Asrar

Omar Assaf

Raine Astin-Chamberlain

Richard Athay-Hunt

Deborah Athorne

Billie Atkins

Christopher Atkins

Stacey Atkins

John Atkinson

Vicki Atkinson

Brygitta Atraskiewicz

Claire Atterbury

Abdul Ahmad Attia

Rita Atugonza

Paula Aubrey

Avinash Aujayeb

Aye Chan Thar Aung

Hnin Aung

Kyaw Thu Aung

Ni Aung

Yin Aung

Zaw Myo Aung

Emily Austin

Karen Austin

Abdusshakur Auwal

Miriam Avery

Joanne Avis

Georgina Aviss

Cristina Avram

Paula Avram

Gabriel Awadzi

Atia Awan

Aszad Aya

Eman Ayaz

Amanda Ayers

Jawwad Azam

Mohammed Azharuddin

Ghazala Aziz

N Aziz

Ali Azkoul

Ashaari Azman Shah

Giada Azzopardi

Hocine Azzoug

Fiyinfoluwa Babatunde

Melvin Babi

Babiker Babiker

Gayna Babington

Matthew Babirecki

Marta Babores

Adetona O Babs-Osibodu

Sammy Bacciarelli

Roudi Bachar

Gina Bacon

Jenny Bacon

Bibi Badal

Gurpreet R Badhan

Shreya Badhrinarayanan

Joseph P Bae

Sibel Bafekr Mishamandani

Alice Baggaley

Amy Baggott

Graham Bagley

Dinesh Bagmane

Lynsey Bagshaw

Kasra Bahadori

James Bailey

Katie Bailey

Lindsey Bailey

Liz Bailey

Morgan Bailey

Pippa Bailey

Sarah Bailey

Stephen Bailey

Hamish Baillie

J Kenneth Baillie

Jennifer Bain

Sanchia Baines

Vikram Bains

Aimi Baird

David Baird

Susan Baird

Tracy Baird

Yolanda Baird

Aiysha Bajandouh

Charles Baker

Emma Baker

Evelyn Baker

Johanne Baker

Josephine Baker

Kenneth Baker

Rebecca Baker

Terri-Anne Baker

Victoria Baker

Hugh Bakere

Nawar Bakerly

Michelle Baker-Moffatt

Nauman Bakhtiar

Panos Bakoulas

Julie Balaam

Niranjan Balachandran

Andrea Balan

Theodosios Balaskas

Madhu Balasubramaniam

Alison Balcombe

Alexander Baldwin

Ashley Baldwin

Caron Baldwin

Danielle Baldwin

Rebekah Baldwin-Jones

James Balfour

Gagan Bali

Sonya Balkee

Ceri Ball

Kasia Ballard

Amy Ballinger

Ismael Balluz

Craig Balmforth

Emese Balogh

Amir Baluwala

Gabby Bambridge

Alasdair Bamford

Amy Bamford

Peter Bamford

Adefunke Bamgboye

Elizabeth Bancroft

Hollie Bancroft

Tanya Bancroft

Joyce Banda

Krishna Bandaru

Srini Bandi

Nageswar Bandla

Somaditya Bandyopadhyam

Amit Banerjee

Millie Banerjee

Ritwik Banerjee

Harrison Banks

Lauren Banks

Luke Banks

Paul Banks

Oliver Bannister

Bharat Bansal

Robert Banthorpe

Laura Banton

Mariamma Baptist

Tanya Baqai

Ananya Mouli Baral

Desislava Baramova

Alex Barber

Russel Barber

Emma Barbon

Miriam Barbosa

Monica Barbosa

Jamie Barbour

Alexander Barclay

Claire Barclay

George Bardsley

Stephanie Bareford

Shahedal Bari

Amy Barker

Debbie Barker

Helen Barker

Joseph Barker

Leon Barker

Oliver Barker

Kerry Barker-Williams

Sinha Barkha

Juliana Barla

Gavin Barlow

Richard Barlow

Valerie Barlow

James Barnacle

Alex Barnard

Debi Barnes

Nicky Barnes

Theresa Barnes

Calum Barnetson

Amy Barnett

Matthew Barnett

Ashton Barnett-Vanes

William Barnsley

Andrew Barr

David Barr

Shaney Barratt

Manuella Barrera

Amy Barrett

Fiona Barrett

Jessica Barrett

Joe Barry

Jazz Bartholomew

Claire Bartlett

Georgina Bartlett

Greg Barton

Jill Barton

Lorna Barton

Rachael Barton

Rosaleen Baruah

Sonia Baryschpolec

Archana Bashyal

Betsy Basker

Ayten Basoglu

Gilda Bass

John Bassett

G Bassett

Chris Bassford

Pavinder Bassi

Betsy Bassis

Bengisu Bassoy

Victoria Bastion

Anupam Basumatary

Tristan Bate

Harry J Bateman

Ian Bateman

Kathryn Bateman

Vhairi Bateman

Eleanor Bates

Hayley Bates

Michelle Bates

Simon Bates

Sally Batham

Ana Batista

Amit Batla

Dushyant Batra

Donna Batty

Harry Batty

Thomas Batty

Peter Baughan

Miranda Baum

Carina Bautista

Fareha Bawa

Fatima S Bawani

Simon Bax

Lydia Baxter

Matt Baxter

Nicola Baxter

Zachary Baxter

Hannah Bayes

Charlotte Baylem

Lee Bayliss

Eileen Bays

Farid Bazari

Rohit Bazaz

Ahmad Bazli

Laura Beacham

Wendy Beadles

Philip Beak

Andy Beale

Kirk Beard

Jack Bearpark

Karen Beaumont

Dawn Beaumont-Jewell

Theresa Beaver

Sarah Beavis

Christy Beazley

Sarah Beck

Virginia Beckett

Rosie Beckitt

Heidi Beddall

Seonaid Beddows

Deborah Beeby

Gail Beech

Michelle Beecroft

Sally Beer

Jane Beety

Gabriela Bega

Alison Begg

Susan Begg

Sara Beghini

Ayesha Begum

Salman Begum

Selina Begum

Teresa Behan

Jasmine Beharry

Roya Behrouzi

Jon Beishon

Claire Beith

James Belcher

Holly Belfield

Katherine Belfield

Ajay Belgaumkar

Dina Bell

Gareth Bell

Gill Bell

Gillian Bell

Joshua Bell

Lauren Bell

Louise Bell

Nicholas Bell

Pippa Bell

Stephanie Bell

Jennifer L Bell

Jennifer Bellamu

Mary Bellamy

Arianna Bellini

Amanda Bellis

Fionn Bellis

Lesley Bendall

Naveena Benesh

Nicola Benetti

Leonie Benham

Guy Benison-Horner

Alexander Bennett

Ann Bennett

Caroline Bennett

Christopher Bennett

Gillian Bennett

Ian Bennett

Kristopher Bennett

Lorraine Bennett

Sara Bennett

Karen Bennion

Vivienne Benson

Jane Benstead

Andrew Bentley

Dionne Bentley

James Bentley

Ian Benton

Eva Beranova

Matthew Beresford

Colin Bergin

Malin Bergstrom

Jolanta Bernatoniene

Thomas Berriman

Zoe Berry

Marnie Berwick

Kimberley Best

Ans-Mari Bester

Yvonne Beuvink

Emily Bevan

Sarah Bevins

Tom Bewick

Andrew Bexley

Sonay Beyatli

Fenella Beynon

Arjun Bhadi

Sanjay Bhagani

Shiv Bhakta

Rekha Bhalla

Khushpreet Bhandal

Kulbinder Bhandal

Ashwin Bhandari

Sangam Bhandari

Aashutosh Bhanot

Ravina Bhanot

Sruti Bhaskara

Prashanth Bhat

Nikhil Bhatia

Rahul Bhatnagar

Karan Bhatt

Janki Bhayani

Deepika Bhojwani

Salimuzzaman Bhuiyan

Anna Bibby

Fatima Bibi

Naheeda Bibi

Salma Bibi

Tihana Bicanic

Sarah Bidgood

Julie Bigg

Sarah Biggs

Alphonsa Biju

Andras Bikov

Sophie Billingham

Jessica Billings

Carron Bilton

Teodirico Binas

Martin Binney

Alice Binns

Muhammad BinRofaie

Oliver Bintcliffe

Catherine Birch

Jenny Birch

Louann Birch

Janet Birchall

Katherine Birchall

Sam Bird

Sumedha Bird

Charndip Biring

Mark Birt

Raquel Bisa

Kilanalei Bishop

Linda Bishop

Lisa Bishop

Karen Bisnauthsing

Nibedan Biswas

Sahar Biuk

Karen Blachford

Ethel Black

Helen Black

Karen Black

Mairead Black

Polly Black

Hayley Blackgrove

Bethan Blackledge

Joanne Blackler

Samantha Blackley

Helen Blackman

Stuart Blackmore

Caroline Blackstock

Loraine Blackwood

Francesca Blakemore

Helen Blamey

Alison Bland

Sujata Blane

Simon Blankley

Mary Blanton

Parry Blaxill

Jenny Blaxland

Katie Blaylock

Jane Blazeby

Carol Blears

Natalie Blencowe

Donna Blofield

Ben Bloom

Jack Bloomfield

Angela Bloss

Hannah Bloxham

Louise Blundell

Andrew Blunsum

Mark Blunt

Ian Blyth

Kevin Blyth

Andrew Blythe

Karen Blythe

Marilyn Boampoaa

Boniface Bobie

Karen Bobruk

Pritesh Bodalia

Neena Bodasing

Tanya Bodenham

Sherin Bodh

Gabriele Boehmer

Marta Boffito

Kristyna Bohmova

Sumit Bokhandi

Maria Bokhar

Saba Bokhari

Sakina Bokhari

Syed Owais Bokhari

Ambrose Boles

Sarah Bollington

Sam Bolton

Charlotte Bomken

Charlotte Bond

Hayley Bond

Helena Bond

Stuart Bond

Thomas Bond

Alice Bone

Georgia Boniface

Wendy Bonnert

Lizzy Bonney

Leigh Boorman

Catherine Booth

Joanne Borbone

Cameron Borhani

Naomi Borman

Rachel Borrell

Mamu Boshir

Fiona Bottrill

Laura Bough

Hayley Boughton

Zoe Boult

Miriam Bourke

Stephen Bourke

Michelle Bourne

Rachel Bousfield

Lucy Boustred

Darren Bowen

Kaye Bowen

Alexandra Bowes

Amy Bowes

Philip Bowker

Louise Bowman

Simon Bowman

Rachel Bowmer

Angie Bowring

Geoff Bowyer

Helen Bowyer

Carmel Boyd

Jenny Boyd

Laura Boyd

Maxine Boyd

Namoi Boyle

Pauline Boyle

Rosalind Boyle

Louise Boyles

Osman Bozdag

Leanna Brace

David Brack

Charlotte Brackstone

Rob Bradburn

Jodie Bradder

Barry Bradley

Clare Jane Bradley

Pamela Bradley

Patrick Bradley

Paul Bradley

Joanne Bradley-Potts

Lynne Bradshaw

Sarah Bradshaw

Zena Bradshaw

Rebecca Brady

Shirin Brady

Denise Braganza

Suhail Brailsford

Jill Braithwaite

Marie Branch

Thomas Brankin-Frisby

Jamie Brannigan

Louise Brassington

Sophie Brattan

Fiona Bray

Nancy Bray

Angela Brazier

Manny Brazil

Lucy Brear

Tracy Brear

Stephen Brearey

Laura Bremner

Morwenna Brend

Giovanna Bretland

Chris Brewer

Hannah Bridge

Gavin Bridgwood

Hayley Briggs

Mark Briggs

Sara Brigham

John Bright

Chris Brightling

Lutece Brimfield

Elaine Brinkworth

Robin Brittain-Long

Vianne Britten

Terri Brittin

Lauren Broad

Sarah Broad

Rosie Broadhurst

Andrew Broadley

Marie Broadway

Christopher Brockelsby

Megan Brocken

Tomos Brockley

Andrew Broderick

Mary Brodsky

Fiona Brogan

David Broggio

Liz Brohan

Felicity Brokke

Jacob Brolly

David Bromley

Hannah Brooke-Ball

Verity Brooker

Ceri Brookes

Matthew Brookes

Alison Brooks

Karen Brooks

Nicole Brooks

Philip Brooks

Rachel Brooks

Sophie Brooks

Natalie Broomhead

Chloe Broughton

Nathaniel Broughton

Matt Brouns

Marie Browett

Alison Brown

Ammani Brown

Carly Brown

Catrin Brown

Chloe Brown

Elizabeth Brown

Ellen Brown

Heather Brown

Janet Brown

Louise Brown

Niall Brown

Pauline Brown

Rachel Brown

Richard Brown

Robert Brown

Steven Brown

Tom Brown

Wayne Brown

Bria Browne

Charlotte Browne

Duncan Browne

Mitchell Browne

Stephen Brownlee

Alba Brraka

David Bruce

Johanna Bruce

Michelle Bruce

Wojciech Brudlo

Nigel Brunskill

Alan Brunton

Margaret Brunton

Mandy Bryan

Meera Bryant

April Buazon

Maya Buch

Julie Buchan

Ruaridh Buchan

Alexis Buchanan

Ruaridh Buchanan

Danielle Buche

Amanda Buck

Matthew Buckland

Laura Buckley

Philip Buckley

Sarah Buckley

Carol Buckman

Kathleen Buckmire

George Bugg

Ramadan Bujazia

Marwan Bukhari

Shanze Bukhari

Richard Bulbulia

Alex Bull

Damian Bull

Rhian Bull

Thomas Bull

Naomi Bulteel

Kasun Bumunarachchi

Roneleeh Bungue-Tuble

Caroline Burchett

Dorota Burda

Christy Burden

Thomas G Burden

Mika Burgess

Paula Burgess

Richard Burgess

Sophia Burgess

Paula Burgett

Adrian Burman

Sara Burnard

Caroline Burnett

John Burnett

Amanda Burns

Amy Burns

Collette Burns

James Burns

Karen Burns

Samuel Burns

Sarah Burns

Daniel Burrage

Sadie Burrage

Kate Burrows

Claire Burston

Ben Burton

Fiona Burton

Matthew Burton

Angela Busby

Deborah Butcher

Aaron Butler

Jessica Butler

Joanne Butler

Joshua Butler

Lesley Butler

Peter Butler

Susan Butler

Al-Tahoor Butt

Mohammad M Butt

Sophia Butt

Caryl Butterworth

Nicola Butterworth-Cowin

Robert Buttery

Tom Buttle

Heather Button

Daniel Buttress

Jane Byrne

Wendy Byrne

Victoria Byrne-Watts

Eleanor Byworth

Amanda Cabandugama

Ruth Cade

Anthony Cadwgan

Donna Cairney

James Calderwood

Darren Caldow

Moira Caldwell

Giorgio Calisti

Debbie Callaghan

Jennifer Callaghan

Claire Callens

Donaldson Callum

Caroline Calver

Melissa Cambell-Kelly

Tracey Camburn

David R Cameron

Eleanor Cameron

Fraser Cameron

Sarah Cameron

Sheena Cameron

Christian Camm

Renee F D Cammack

Alison Campbell

Amy Campbell

Barbara Campbell

Bridget Campbell

Debbie Campbell

Helen Campbell

Hilary Campbell

Jonathan Campbell

Mark Campbell

Robyn Campbell

Wynny Campbell

Quentin Campbell Hewson

Julie Camsooksai

Ana Canabarro

Lisa Canclini

Shaula Mae Candido

Janie Candlish

Cielito Caneja

Johnathon Cann

Ruby Cannan

Emma Cannon

Michael Cannon

Petra Cannon

Vivienne Cannons

Jane Cantliff

Ben Caplin

Santino Capocci

Noemi Caponi

Angelika Capp

Anne Capps-Jenner

Thomas Capstick

Ishmael Carboo

Nuria Cardenas

Mary Cardwell

Rachel Carey

Simon Carley

Tammy Carlin

Andrew Carlton

Samantha Carmichael

Mandy Carnahan

Rebecca Carnegie

Charlotte Caroline

Emily Carpenter

Jodi Carpenter

David Carr

Sharon Carr

Anna Carrasco

Samantha Carrington

Zoe Carrington

Paul Carroll

Caroline Carron

Anne Carstairs

Jonathan Carter

Michael Carter

Moira Carter

Paul Carter

Penny Carter

Steven Carter

Simon Carter-Graham

Douglas Cartwright

Jo-Anne Cartwright

Claire Carty

Sinead Carty

Jaime Carungcong

Carolyn Carveth-Marshall

Susan Casey

Annie Cassells

Barbara Cassimon

Teresa Castiello

Gail Castle

Bridget Castles

Melanie Caswell

Ana Maria Catana

Heidi Cate

Susanne Cathcart

Katrina Cathie

Christine Catley

Laura Catlow

Matthew Caudwell

Jill Caulfield

Anna Cavazza

Luke Cave

Simon Cavinato

Frianne Cawa

Kathryn Cawley

Chloe Caws

Hankins Cendl

Hannah Century

Jeva Cernova

Mansur Cesay

Ed Cetti

Stephanie Chabane

Manish Chablani

Cathleen Chabo

David Chadwick

Julie Chadwick

Robert Chadwick

Ela Chakkarapani

Arup Chakraborty

Mallinath Chakraborty

Mollika Chakravorty

James Chalmers

Richard Chalmers

Georgina Chamberlain

Sarah Chamberlain

Emma Chambers

Jonathan Chambers

Lucy Chambers

Naomi Chambers

Alex Chan

Carmen Chan

Cheuk Chan

Evelyn Chan

Kayen Chan

Kimberley Chan

Ping Chan

Rebekah (Pui-Ching) Chan

Xin Hui Chan

Chris Chandler

Heidi Chandler

Kim J Chandler

Stuart Chandler

Zoe Chandler

Vikki Chandler-Vizard

Sumit Chandra

Navin Chandran

Badrinathan Chandrasekaran

Cherry Chang

Yvonne Chang

Josephine Chaplin

Graeme Chapman

John Chapman

Katie Chapman

Laura Chapman

Lianne Chapman

Polly Chapman

Timothy Chapman

Lucy Chappell

Linda Chapple

Amanda Charalambou

Bethan Charles

Dianne Charlton

Sally Charlton

Kevin Chatar

Calvin Chatha

Ritesh Chaube

Muhammad YN Chaudhary

Iram Chaudhry

Nazia Chaudhuri

Muhammad Chaudhury

Anoop Chauhan

Ruchi S Chauhan

Vipul Chauhan

Nicola Chavasse

Iknam Chaven

Rosanna Chavez

Vipal Chawla

Maria Cheadle

Lindsay Cheater

James Cheaveau

Charlotte Cheeld

Michelle Cheeseman

Fang Chen

Hui Min Chen

Terence Chen

Lok Yin Cheng

Zhihang Cheng

Helen Chenoweth

Chun How Cheong

Shiney Cherian

Suzanne Cherif

Mary Cherrie

Helen Cheshire

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Theodora Francis-Bacon

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Ankur Gupta-Wright

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Abstract

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research.

Citation

Abani, O., Abbas, A., Abbas, F., Abbas, M., Abbasi, S., Abbass, H., …Zyengi, S. (2021). Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. Lancet, 397(10289), 2049-2059. https://doi.org/10.1016/s0140-6736%2821%2900897-7

Journal Article Type Article
Acceptance Date Apr 12, 2021
Online Publication Date May 14, 2021
Publication Date May 29, 2021
Deposit Date Aug 3, 2021
Publicly Available Date Aug 3, 2021
Journal The Lancet
Print ISSN 0140-6736
Electronic ISSN 1474-547X
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 397
Issue 10289
Pages 2049-2059
DOI https://doi.org/10.1016/s0140-6736%2821%2900897-7
Keywords General Medicine
Public URL https://nottingham-repository.worktribe.com/output/5943713
Publisher URL https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00897-7/fulltext
Additional Information Authors on behalf of RECOVERY Collaborative Group.

University of Nottingham authors: Ed Juszczak, Alan Montgomery. Fellow linked author, Lim Wei Shen.

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