Ratlas-LH: An MRI template of the Lister hooded rat brain with stereotaxic coordinates for neurosurgical implantations

Prior, Malcolm J.W.; Bast, Tobias; McGarrity, Stephanie; Goldschmidt, Jürgen; Vincenz, Daniel; Seaton, Adam; Hall, Gerard; Pitiot, Alain

Abstract

There is currently no brain atlas available to specifically determine stereotaxic coordinates for neurosurgery in Lister hooded rats despite the popularity of this strain for behavioural neuroscience studies in the UK and elsewhere. We have created a dataset, which we refer to as 'Ratlas-LH' (for Lister hooded). Ratlas-LH combines in vivo magnetic resonance images of the brain of young adult male Lister hooded rats with micro-computed tomography images of the ex vivo skull, as well as a set of delineations of brain regions, adapted from the Waxholm Space Atlas of the Sprague Dawley Rat Brain. Ratlas-LH was produced with an isotropic resolution of 0.15 mm. It has been labelled in such a way as to provide a stereotaxic coordinate system for the determination of distances relative to the skull landmark of bregma. We have demonstrated that the atlas can be used to determine stereotaxic coordinates to accurately target brain regions in the Lister hooded rat brain. Ratlas-LH is freely available to facilitate neurosurgical procedures in the Lister hooded rat. https://mc.manuscriptcentral.com/bna Brain and Neuroscience Advances

Citation

Prior, M. J., Bast, T., McGarrity, S., Goldschmidt, J., Vincenz, D., Seaton, A., …Pitiot, A. (2021). Ratlas-LH: An MRI template of the Lister hooded rat brain with stereotaxic coordinates for neurosurgical implantations. Brain and Neuroscience Advances, 5,

• Journal Article Type: Article
• Acceptance Date: Jul 13, 2021
• Online Publication Date: Aug 10, 2021
• Publication Date: Aug 10, 2021
• Deposit Date: Jul 13, 2021
• Publicly Available Date: Aug 10, 2021
• Journal: Brain and Neuroscience Advances
• Electronic ISSN: 2398-2128
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 5
• Keywords: Stereotaxic; brain atlas; Lister hooded rat; MRI; micro-CT
• Public URL: https://nottingham-repository.worktribe.com/output/5782993
• Publisher URL: https://journals.sagepub.com/doi/10.1177/23982128211036332