Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1

Pobric, Gorana; Taylor, Jason R.; Ramalingam, Hemavathy M.; Pye, Emily; Robinson, Louise; Vassallo, Grace; Jung, JeYoung; Bhandary, Misty; Szumanska-Ryt, Karolina; Theodosiou, Louise; Evans, D. Gareth; Eelloo, Judith; Burkitt-Wright, Emma; Hulleman, Johan; Green, Jonathan; Garg, Shruti

doi:10.1007/s10803-021-05043-3

Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1

Pobric, Gorana; Taylor, Jason R.; Ramalingam, Hemavathy M.; Pye, Emily; Robinson, Louise; Vassallo, Grace; Jung, JeYoung; Bhandary, Misty; Szumanska-Ryt, Karolina; Theodosiou, Louise; Evans, D. Gareth; Eelloo, Judith; Burkitt-Wright, Emma; Hulleman, Johan; Green, Jonathan; Garg, Shruti

Authors

Gorana Pobric

Jason R. Taylor

Hemavathy M. Ramalingam

Emily Pye

Louise Robinson

Grace Vassallo

Dr JEYOUNG JUNG Jeyoung.Jung@nottingham.ac.uk
Assistant Professor

Misty Bhandary

Karolina Szumanska-Ryt

Louise Theodosiou

D. Gareth Evans

Judith Eelloo

Emma Burkitt-Wright

Johan Hulleman

Jonathan Green

Shruti Garg

Abstract

Neurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded during a WM nback task. The NF1 group showed poorer performance on measures of WM as compared to the control group. No group differences were observed in P300 amplitude at Pz, but P300 latency was shorter in the NF1 group. Topographic analyses of P300 amplitude showed group differences indicating neural processing differences in the NF1 group relative to controls, which possibly contribute to the cognitive deficits seen in this population.

Citation

Pobric, G., Taylor, J. R., Ramalingam, H. M., Pye, E., Robinson, L., Vassallo, G., …Garg, S. (2022). Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1. Journal of Autism and Developmental Disorders, 52(4), 1478-1494. https://doi.org/10.1007/s10803-021-05043-3

Journal Article Type	Article
Acceptance Date	Apr 21, 2021
Online Publication Date	May 8, 2021
Publication Date	2022-04
Deposit Date	Jul 12, 2021
Publicly Available Date	Jul 13, 2021
Journal	Journal of Autism and Developmental Disorders
Print ISSN	0162-3257
Electronic ISSN	1573-3432
Publisher	Springer Verlag
Peer Reviewed	Peer Reviewed
Volume	52
Issue	4
Pages	1478-1494
DOI	https://doi.org/10.1007/s10803-021-05043-3
Keywords	Developmental and Educational Psychology
Public URL	https://nottingham-repository.worktribe.com/output/5781821
Publisher URL	https://link.springer.com/article/10.1007%2Fs10803-021-05043-3