Electric Field Induced Biomimetic Transmembrane Electron Transport Using Carbon Nanotube Porins

Hicks, Jacqueline M.; Yao, Yun-Chiao; Barber, Sydney; Neate, Nigel; Watts, Julie A.; Noy, Aleksandr; Rawson, Frankie J.

Abstract

Cells modulate their homeostasis through the control of redox reactions via transmembrane electron transport systems. These are largely mediated via oxidoreductase enzymes. Their use in biology has been linked to a host of systems including reprogramming for energy requirements in cancer. Consequently, the ability to modulate membrane redox systems may give rise to opportunities to modulate underlying biology. The current work aims to develop a wireless bipolar electrochemical approach to form on-demand electron transfer across biological membranes. To achieve this goal, it is shown that by using membrane inserted carbon nanotube porins (CNTPs) that can act as bipolar nanoelectrodes, one can control electron flow with externally applied electric fields across membranes. Before this work, bipolar electrochemistry has been thought to require high applied voltages not compatible with biological systems. It is shown that bipolar electrochemical reaction via gold reduction at the nanotubes can be modulated at low cell-friendly voltages, providing an opportunity to use bipolar electrodes to control electron flux across membranes. The authors provide new mechanistic insight into this newly describe phenomena at the nanoscale. The results presented give rise to a new method using CNTPs to modulate cell behavior via wireless control of membrane electron transfer.

Citation

Hicks, J. M., Yao, Y., Barber, S., Neate, N., Watts, J. A., Noy, A., & Rawson, F. J. (2021). Electric Field Induced Biomimetic Transmembrane Electron Transport Using Carbon Nanotube Porins. Small, 17(32), Article 2102517. https://doi.org/10.1002/smll.202102517

• Journal Article Type: Article
• Acceptance Date: Mar 21, 2021
• Online Publication Date: Jul 16, 2021
• Publication Date: Aug 12, 2021
• Deposit Date: Jun 22, 2021
• Publicly Available Date: Jul 17, 2022
• Journal: Small
• Print ISSN: 1613-6810
• Electronic ISSN: 1613-6829
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 32
• Article Number: 2102517
• DOI: https://doi.org/10.1002/smll.202102517
• Keywords: Biomaterials; Biotechnology; General Materials Science; General Chemistry
• Public URL: https://nottingham-repository.worktribe.com/output/5718372
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/smll.202102517