Decoupling manufacturing from application in additive manufactured antimicrobial materials

Wales, Dominic J.; Miralles-Comins, Sara; Franco-Castillo, Isabel; Cameron, Jamie M.; Cao, Qun; Karjalainen, Erno; Alves Fernandes, Jesum; Newton, Graham N.; Mitchell, Scott G.; Sans, Victor

Abstract

3D printable materials based on polymeric ionic liquids (PILs) capable of controlling the synthesis and stabilisation of silver nanoparticles (AgNPs) and their synergistic antimicrobial activity are reported. The interaction of the ionic liquid moieties with the silver precursor enabled the controlled in situ formation and stabilisation of AgNPs via extended UV photoreduction after the printing process, thus demonstrating an effective decoupling of the device manufacturing from the on-demand generation of nanomaterials, which avoids the potential aging of the nanomaterials through oxidation. The printed devices showed a multi-functional and tuneable microbicidal activity against Gram positive (B. subtilis) and Gram negative (E. coli) bacteria and against the mould Aspergillus niger. While the polymeric material alone was found to be bacteriostatic, the AgNPs conferred bactericidal properties to the material. Combining PIL-based materials with functionalities, such as in situ and photoactivated on-demand fabricated antimicrobial AgNPs, provides a synergistic functionality that could be harnessed for a variety of applications, especially when coupled to the freedom of design inherent to additive manufacturing techniques.

Citation

Wales, D. J., Miralles-Comins, S., Franco-Castillo, I., Cameron, J. M., Cao, Q., Karjalainen, E., …Sans, V. (2021). Decoupling manufacturing from application in additive manufactured antimicrobial materials. Biomaterials Science, 9(16), 5397-5406. https://doi.org/10.1039/d1bm00430a

• Journal Article Type: Article
• Acceptance Date: May 10, 2021
• Online Publication Date: May 11, 2021
• Publication Date: Aug 21, 2021
• Deposit Date: Jun 25, 2021
• Publicly Available Date: Jun 25, 2021
• Journal: Biomaterials Science
• Electronic ISSN: 2047-4849
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 16
• Pages: 5397-5406
• DOI: https://doi.org/10.1039/d1bm00430a
• Keywords: General Materials Science; Biomedical Engineering
• Public URL: https://nottingham-repository.worktribe.com/output/5535633
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2021/BM/D1BM00430A#!divAbstract
• Additional Information: : This document is Similarity Check deposited; : Supplementary Information; : Dominic J. Wales (ORCID); : Dominic J. Wales (ResearcherID); : Jamie M. Cameron (ORCID); : Jesum Alves Fernandes (ORCID); : Jesum Alves Fernandes (ResearcherID); : Graham N. Newton (ORCID); : Graham N. Newton (ResearcherID); : Scott G. Mitchell (ORCID); : Scott G. Mitchell (ResearcherID); : Victor Sans (ORCID); : Victor Sans (ResearcherID); : Single-blind; : Received 19 March 2021; Accepted 10 May 2021; Accepted Manuscript published 11 May 2021; Advance Article published 14 May 2021